| pubmed-article:2166509 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C0145988 | lld:lifeskim |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C0623362 | lld:lifeskim |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:2166509 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:2166509 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2166509 | pubmed:dateCreated | 1990-9-10 | lld:pubmed |
| pubmed-article:2166509 | pubmed:abstractText | We have investigated the effect of interleukin 6 (IL-6) on the synthesis of tissue inhibitor of metalloproteinases (TIMP) and matrix metalloproteinases (MMPs), collagenase (MMP-1) and stromelysin (MMP-3) using human skin and uterine cervical fibroblasts. IL-6 did not modulate the expression of MMPs by these fibroblasts, but the production of TIMP was enhanced by IL-6 in a dose dependent manner, whereas IL-1 stimulated the production of both MMPs and TIMP. The combination of IL-6 and IL-1 further augmented IL-1-induced MMPs and TIMP production. The results provide the first evidence that IL-6 participates in the catabolism of the extracellular matrix components by modulating the effects of IL-1 on MMPs and TIMP synthesis as well as its direct effects on the synthesis of TIMP by connective tissue cells. | lld:pubmed |
| pubmed-article:2166509 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2166509 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2166509 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2166509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2166509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2166509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2166509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2166509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2166509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2166509 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2166509 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2166509 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:2166509 | pubmed:author | pubmed-author:SatoTT | lld:pubmed |
| pubmed-article:2166509 | pubmed:author | pubmed-author:ItoAA | lld:pubmed |
| pubmed-article:2166509 | pubmed:author | pubmed-author:MoriYY | lld:pubmed |
| pubmed-article:2166509 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2166509 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:2166509 | pubmed:volume | 170 | lld:pubmed |
| pubmed-article:2166509 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2166509 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2166509 | pubmed:pagination | 824-9 | lld:pubmed |
| pubmed-article:2166509 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:2166509 | pubmed:meshHeading | pubmed-meshheading:2166509-... | lld:pubmed |
| pubmed-article:2166509 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2166509 | pubmed:articleTitle | Interleukin 6 enhances the production of tissue inhibitor of metalloproteinases (TIMP) but not that of matrix metalloproteinases by human fibroblasts. | lld:pubmed |
| pubmed-article:2166509 | pubmed:affiliation | Department of Biochemistry, Tokyo College of Pharmacy, Japan. | lld:pubmed |
| pubmed-article:2166509 | pubmed:publicationType | Journal Article | lld:pubmed |
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