| pubmed-article:21637796 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C1185625 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C0008546 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C0253166 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C1325722 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C1512486 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C1335840 | lld:lifeskim |
| pubmed-article:21637796 | lifeskim:mentions | umls-concept:C1335844 | lld:lifeskim |
| pubmed-article:21637796 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21637796 | pubmed:dateCreated | 2011-6-3 | lld:pubmed |
| pubmed-article:21637796 | pubmed:abstractText | The complexity in composition and function of the eukaryotic nucleus is achieved through its organization in specialized nuclear compartments. The Drosophila chromatin remodeling ATPase ISWI plays evolutionarily conserved roles in chromatin organization. Interestingly, ISWI genetically interacts with the hsr? gene, encoding multiple non-coding RNAs (ncRNA) essential, among other functions, for the assembly and organization of the omega speckles. The nucleoplasmic omega speckles play important functions in RNA metabolism, in normal and stressed cells, by regulating availability of hnRNPs and some other RNA processing proteins. Chromatin remodelers, as well as nuclear speckles and their associated ncRNAs, are emerging as important components of gene regulatory networks, although their functional connections have remained poorly defined. Here we provide multiple lines of evidence showing that the hsr? ncRNA interacts in vivo and in vitro with ISWI, regulating its ATPase activity. Remarkably, we found that the organization of nucleoplasmic omega speckles depends on ISWI function. Our findings highlight a novel role for chromatin remodelers in organization of nucleoplasmic compartments, providing the first example of interaction between an ATP-dependent chromatin remodeler and a large ncRNA. | lld:pubmed |
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| pubmed-article:21637796 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21637796 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21637796 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21637796 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21637796 | pubmed:month | May | lld:pubmed |
| pubmed-article:21637796 | pubmed:issn | 1553-7404 | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:CoronaDavide... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:LakhotiaSubha... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:SinghAnand... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:MallikMousham... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:IngrassiaAnto... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:OnoratiMaria... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:LazzaroSandra... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:CarrecaAnna... | lld:pubmed |
| pubmed-article:21637796 | pubmed:author | pubmed-author:ChaturvediDeo... | lld:pubmed |
| pubmed-article:21637796 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21637796 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:21637796 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21637796 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21637796 | pubmed:pagination | e1002096 | lld:pubmed |
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| pubmed-article:21637796 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21637796 | pubmed:articleTitle | The ISWI chromatin remodeler organizes the hsr? ncRNA-containing omega speckle nuclear compartments. | lld:pubmed |
| pubmed-article:21637796 | pubmed:affiliation | Dulbecco Telethon Institute c/o Università degli Studi di Palermo, Dipartimento STEMBIO – Sezione Biologia Cellulare, Palermo, Italy. | lld:pubmed |
| pubmed-article:21637796 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21637796 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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