| pubmed-article:21622095 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C1427643 | lld:lifeskim |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:21622095 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:21622095 | pubmed:dateCreated | 2011-5-30 | lld:pubmed |
| pubmed-article:21622095 | pubmed:abstractText | Pirh2 is an E3 ligase that negatively regulates p53 through both direct physical interaction and ubiquitin-mediated proteolysis. Here, we identified a novel Pirh2-interacting protein, AIG1, by yeast two-hybrid screening and confirmed its interaction with p53 both in vitro and in vivo. Quantitative real-time reverse transcription-PCR analysis showed that AIG1 expression levels were reduced in 50 out of 79 (63%) human hepatocellular carcinomas (HCCs) when compared to matched, non-cancerous liver tissue; levels were significantly different between HCCs with or without lymph node metastasis. Kaplan-Meier analysis indicated that the survival time of HCC patients down-regulated for AIG1 is much shorter than it is for patients up-regulated for AIG1 expression (p = 0.0313 as determined by the Log-rank test). Finally, AIG1 activated the nuclear factor of activated T cells (NFAT) signaling pathway in a dose-dependent manner when over-expressed in HEK293T cells. Our results suggest AIG1 could serve as a new biomarker for the diagnosis and prognostic evaluation of HCCs. | lld:pubmed |
| pubmed-article:21622095 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21622095 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21622095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21622095 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21622095 | pubmed:issn | 1945-0508 | lld:pubmed |
| pubmed-article:21622095 | pubmed:author | pubmed-author:ZhangWeiW | lld:pubmed |
| pubmed-article:21622095 | pubmed:author | pubmed-author:WuGangG | lld:pubmed |
| pubmed-article:21622095 | pubmed:author | pubmed-author:HuoKekeK | lld:pubmed |
| pubmed-article:21622095 | pubmed:author | pubmed-author:SunMeiqianM | lld:pubmed |
| pubmed-article:21622095 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21622095 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:21622095 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21622095 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21622095 | pubmed:pagination | 834-42 | lld:pubmed |
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| pubmed-article:21622095 | pubmed:meshHeading | pubmed-meshheading:21622095... | lld:pubmed |
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| pubmed-article:21622095 | pubmed:meshHeading | pubmed-meshheading:21622095... | lld:pubmed |
| pubmed-article:21622095 | pubmed:meshHeading | pubmed-meshheading:21622095... | lld:pubmed |
| pubmed-article:21622095 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21622095 | pubmed:articleTitle | AIG1 is a novel Pirh2-interacting protein that activates the NFAT signaling pathway. | lld:pubmed |
| pubmed-article:21622095 | pubmed:affiliation | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, PR China. | lld:pubmed |
| pubmed-article:21622095 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21622095 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:25898 | entrezgene:pubmed | pubmed-article:21622095 | lld:entrezgene |
| entrez-gene:51390 | entrezgene:pubmed | pubmed-article:21622095 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21622095 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21622095 | lld:entrezgene |
