| pubmed-article:2160427 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C0148323 | lld:lifeskim |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C0032535 | lld:lifeskim |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:2160427 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:2160427 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:2160427 | pubmed:dateCreated | 1990-6-25 | lld:pubmed |
| pubmed-article:2160427 | pubmed:abstractText | Polymyxin B, an amphipathic cyclic decapeptide produced by Bacillus polymyxa, is routinely used in the extraction of the components from the periplasmic space of gram-negative bacteria. Vero cytotoxin 1 (VT1) is an Escherichia coli-elaborated subunit toxin which binds to the glycolipid globotriosylceramide (Gal-alpha 1-4-Gal beta 1-4-Glc-ceramide [Gb3]) and has been strongly implicated in the etiology of the hemolytic uremic syndrome and hemorrhagic colitis. We now show by in vitro glycolipid-binding assays that in the presence of low concentrations of polymyxin B, globotetraosylceramide (GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc-ceramide [Gb4]) is also recognized by both the VT1 B (binding) subunit and holotoxin. Melittin, a 26-amino-acid cyclic peptide of similar amphipathic nature, produced the same effect, whereas a hydrophobic blocking agent did not. Triton X-100 did not increase binding of VT1 to Gb4 but prevented glycolipid binding in toto at concentrations above 0.5%. Caution is therefore advised in the analysis of VT1 glycolipid binding in the presence of amphipathic peptides. | lld:pubmed |
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| pubmed-article:2160427 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2160427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2160427 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2160427 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2160427 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2160427 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:2160427 | pubmed:author | pubmed-author:LingwoodCC | lld:pubmed |
| pubmed-article:2160427 | pubmed:author | pubmed-author:HeadSS | lld:pubmed |
| pubmed-article:2160427 | pubmed:author | pubmed-author:RamotarKK | lld:pubmed |
| pubmed-article:2160427 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2160427 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:2160427 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2160427 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2160427 | pubmed:pagination | 1532-7 | lld:pubmed |
| pubmed-article:2160427 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2160427 | pubmed:meshHeading | pubmed-meshheading:2160427-... | lld:pubmed |
| pubmed-article:2160427 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2160427 | pubmed:articleTitle | Modification of the glycolipid-binding specificity of vero cytotoxin by polymyxin B and other cyclic amphipathic peptides. | lld:pubmed |
| pubmed-article:2160427 | pubmed:affiliation | Department of Microbiology, Hospital for Sick Children, Toronto, Ontario. | lld:pubmed |
| pubmed-article:2160427 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2160427 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:2160427 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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