| pubmed-article:21596592 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21596592 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:21596592 | lifeskim:mentions | umls-concept:C0018188 | lld:lifeskim |
| pubmed-article:21596592 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21596592 | lifeskim:mentions | umls-concept:C0206431 | lld:lifeskim |
| pubmed-article:21596592 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:21596592 | lifeskim:mentions | umls-concept:C0439801 | lld:lifeskim |
| pubmed-article:21596592 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21596592 | pubmed:dateCreated | 2011-5-27 | lld:pubmed |
| pubmed-article:21596592 | pubmed:abstractText | Cell-mediated adaptive immunity is critical for host defense, but little is known about T cell behavior during delivery of effector function. Here we investigate relationships among antigen presentation, T cell motility, and local production of effector cytokines by CD4+ T cells within hepatic granulomas triggered by Bacille Calmette-Guérin or Mycobacterium tuberculosis. At steady-state, only small fractions of mycobacteria-specific T cells showed antigen-induced migration arrest within granulomas, resulting in low-level, polarized secretion of cytokines. However, exogenous antigen elicited rapid arrest and robust cytokine production by the vast majority of effector T cells. These findings suggest that limited antigen presentation and/or recognition within granulomas evoke a muted T cell response drawing on only a fraction of the host's potential effector capacity. Our results provide new insights into the regulation of host-protective functions, especially how antigen availability influences T cell dynamics and, in turn, effector T cell function during chronic infection. | lld:pubmed |
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| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21596592 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21596592 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21596592 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21596592 | pubmed:month | May | lld:pubmed |
| pubmed-article:21596592 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:21596592 | pubmed:author | pubmed-author:EgenJackson... | lld:pubmed |
| pubmed-article:21596592 | pubmed:author | pubmed-author:FengCarl GCG | lld:pubmed |
| pubmed-article:21596592 | pubmed:author | pubmed-author:HorwitzMarcus... | lld:pubmed |
| pubmed-article:21596592 | pubmed:author | pubmed-author:SherAlanA | lld:pubmed |
| pubmed-article:21596592 | pubmed:author | pubmed-author:GermainRonald... | lld:pubmed |
| pubmed-article:21596592 | pubmed:author | pubmed-author:RothfuchsAnto... | lld:pubmed |
| pubmed-article:21596592 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21596592 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21596592 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:21596592 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:21596592 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21596592 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21596592 | pubmed:pagination | 807-19 | lld:pubmed |
| pubmed-article:21596592 | pubmed:dateRevised | 2011-9-13 | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
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| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:meshHeading | pubmed-meshheading:21596592... | lld:pubmed |
| pubmed-article:21596592 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21596592 | pubmed:articleTitle | Intravital imaging reveals limited antigen presentation and T cell effector function in mycobacterial granulomas. | lld:pubmed |
| pubmed-article:21596592 | pubmed:affiliation | Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:21596592 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21596592 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21596592 | lld:pubmed |
