| pubmed-article:2157380 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0344315 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0029297 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0683150 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0005456 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:2157380 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:2157380 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2157380 | pubmed:dateCreated | 1990-4-30 | lld:pubmed |
| pubmed-article:2157380 | pubmed:abstractText | The plasma concentration of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the site labeled by tritiated imipramine, was measured by a radial immunodiffusion assay in 36 normal human volunteers and 51 drug-free patients who fulfilled DSM-III criteria for major depression. The depressed patients exhibited a significant elevation in the plasma concentration (+/- SEM) of alpha 1-acid glycoprotein (79.6 +/- 4 mg/dL) when compared with the age- and sex-matched controls (61.7 +/- 3 mg/dL). Fourteen of the 51 patients with major depression had plasma alpha 1-acid glycoprotein concentrations that were higher than the highest values of the normal controls. There was no relationship between plasma alpha 1-acid glycoprotein concentrations and sex or affinity of platelet tritiated imipramine binding of either the normal volunteers or the depressed patients. In the depressed patients, there was a significant positive correlation between plasma concentrations of alpha 1-acid glycoprotein and postdexamethasone plasma cortisol concentrations, and two measures of depression severity, the Montgomery-Asberg Rating Scale for Depression and the Center for Epidemiologic Studies-Depression Scale, and a significant negative correlation with age. These data provide the first evidence of alterations of an endogenous inhibitor of the tritiated imipramine binding site/serotonin transporter in depressed patients. | lld:pubmed |
| pubmed-article:2157380 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2157380 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2157380 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2157380 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2157380 | pubmed:issn | 0003-990X | lld:pubmed |
| pubmed-article:2157380 | pubmed:author | pubmed-author:MeyersonL RLR | lld:pubmed |
| pubmed-article:2157380 | pubmed:author | pubmed-author:NemeroffC BCB | lld:pubmed |
| pubmed-article:2157380 | pubmed:author | pubmed-author:BenjaminDD | lld:pubmed |
| pubmed-article:2157380 | pubmed:author | pubmed-author:KrishnanK RKR | lld:pubmed |
| pubmed-article:2157380 | pubmed:author | pubmed-author:KnightD LDL | lld:pubmed |
| pubmed-article:2157380 | pubmed:author | pubmed-author:BlazerD GDG | lld:pubmed |
| pubmed-article:2157380 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2157380 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:2157380 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2157380 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2157380 | pubmed:pagination | 337-40 | lld:pubmed |
| pubmed-article:2157380 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
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| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:meshHeading | pubmed-meshheading:2157380-... | lld:pubmed |
| pubmed-article:2157380 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2157380 | pubmed:articleTitle | Elevated plasma concentrations of alpha 1-acid glycoprotein, a putative endogenous inhibitor of the tritiated imipramine binding site, in depressed patients. | lld:pubmed |
| pubmed-article:2157380 | pubmed:affiliation | Department of Psychiatry, Duke University Medical Center, Durham, NC. | lld:pubmed |
| pubmed-article:2157380 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2157380 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
