Linked Life Data

21499248

Source:http://linkedlifedata.com/resource/pubmed/id/21499248

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pubmed-article:21499248pubmed:dateCreated2011-4-27lld:pubmed
pubmed-article:21499248pubmed:abstractTextTo identify the genetic susceptibility factor(s) for hepatitis C virus-induced hepatocellular carcinoma (HCV-induced HCC), we conducted a genome-wide association study using 432,703 autosomal SNPs in 721 individuals with HCV-induced HCC (cases) and 2,890 HCV-negative controls of Japanese origin. Eight SNPs that showed possible association (P < 1 × 10(-5)) in the genome-wide association study were further genotyped in 673 cases and 2,596 controls. We found a previously unidentified locus in the 5' flanking region of MICA on 6p21.33 (rs2596542, P(combined) = 4.21 × 10(-13), odds ratio = 1.39) to be strongly associated with HCV-induced HCC. Subsequent analyses using individuals with chronic hepatitis C (CHC) indicated that this SNP is not associated with CHC susceptibility (P = 0.61) but is significantly associated with progression from CHC to HCC (P = 3.13 × 10(-8)). We also found that the risk allele of rs2596542 was associated with lower soluble MICA protein levels in individuals with HCV-induced HCC (P = 1.38 × 10(-13)).lld:pubmed
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pubmed-article:21499248pubmed:year2011lld:pubmed
pubmed-article:21499248pubmed:articleTitleGenome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.lld:pubmed
pubmed-article:21499248pubmed:affiliationLaboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.lld:pubmed
pubmed-article:21499248pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21499248pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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