| pubmed-article:21497174 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21497174 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:21497174 | lifeskim:mentions | umls-concept:C0008838 | lld:lifeskim |
| pubmed-article:21497174 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:21497174 | lifeskim:mentions | umls-concept:C1742737 | lld:lifeskim |
| pubmed-article:21497174 | lifeskim:mentions | umls-concept:C0025938 | lld:lifeskim |
| pubmed-article:21497174 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21497174 | pubmed:dateCreated | 2011-7-11 | lld:pubmed |
| pubmed-article:21497174 | pubmed:abstractText | Benefits of the frequently prescribed platinum (II) chemotherapy drugs are compromised by undesirable side effects, poor pharmacokinetics and development of drug resistance. Polymer micelles derived from amphiphilic block copolymers, offer a novel macromolecular platform for carrier based delivery of such compounds. Soft polymeric nanocarriers were synthesized by template-assisted method involving condensation of the poly(ethylene oxide)-b-polymethacrylate anions by metal ions into core-shell block ionomer complex micelles followed by chemical cross-linking of the polyion chains in the micelle cores. The resulting micelles can efficiently incorporate cisplatin with a high loading capacity (up to 42% w/w). Core cross-linking stabilized the micelles against structural disintegration and prevented premature drug release. The reversible cisplatin entrapment involved the carboxylate groups of the micellar core. The drug was released in a pH-responsive manner, without loss of its biological activity. The stable cross-linked polymer micelles can potentially improve platinum (II) drug disposition with improved therapeutic potential. | lld:pubmed |
| pubmed-article:21497174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21497174 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21497174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21497174 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21497174 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:21497174 | pubmed:issn | 1873-4995 | lld:pubmed |
| pubmed-article:21497174 | pubmed:author | pubmed-author:BronichTatian... | lld:pubmed |
| pubmed-article:21497174 | pubmed:author | pubmed-author:KabanovAlexan... | lld:pubmed |
| pubmed-article:21497174 | pubmed:author | pubmed-author:MarkyLuis ALA | lld:pubmed |
| pubmed-article:21497174 | pubmed:author | pubmed-author:LaquerFrederi... | lld:pubmed |
| pubmed-article:21497174 | pubmed:author | pubmed-author:OberoiHardeep... | lld:pubmed |
| pubmed-article:21497174 | pubmed:copyrightInfo | Copyright © 2011 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21497174 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21497174 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21497174 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:21497174 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21497174 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21497174 | pubmed:pagination | 64-72 | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:meshHeading | pubmed-meshheading:21497174... | lld:pubmed |
| pubmed-article:21497174 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21497174 | pubmed:articleTitle | Core cross-linked block ionomer micelles as pH-responsive carriers for cis-diamminedichloroplatinum(II). | lld:pubmed |
| pubmed-article:21497174 | pubmed:affiliation | Department of Pharmaceutical Sciences and Center for Drug Delivery and Nanomedicine, College of Pharmacy, University of Nebraska Medical Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA. | lld:pubmed |
| pubmed-article:21497174 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21497174 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
