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| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C1384616 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C0023449 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C1417102 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:21481790 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:21481790 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21481790 | pubmed:dateCreated | 2011-4-12 | lld:pubmed |
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| pubmed-article:21481790 | pubmed:abstractText | To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular-cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified that lacked rearrangements of known oncogenes. One subtype associated with cortical arrest, expression of cell cycle genes, and ectopic NKX2-1 or NKX2-2 expression for which rearrangements were identified. The second subtype associated with immature T cell development and high expression of the MEF2C transcription factor as consequence of rearrangements of MEF2C, transcription factors that target MEF2C, or MEF2C-associated cofactors. We propose NKX2-1, NKX2-2, and MEF2C as T-ALL oncogenes that are activated by various rearrangements. | lld:pubmed |
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| pubmed-article:21481790 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:21481790 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:21481790 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21481790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21481790 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21481790 | pubmed:issn | 1878-3686 | lld:pubmed |
| pubmed-article:21481790 | pubmed:author | pubmed-author:PietersRobR | lld:pubmed |
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| pubmed-article:21481790 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21481790 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21481790 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:21481790 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:21481790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21481790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21481790 | pubmed:pagination | 484-97 | lld:pubmed |
| pubmed-article:21481790 | pubmed:dateRevised | 2011-7-13 | lld:pubmed |
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| pubmed-article:21481790 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21481790 | pubmed:articleTitle | Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia. | lld:pubmed |
| pubmed-article:21481790 | pubmed:affiliation | Department of Pediatric Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands. | lld:pubmed |
| pubmed-article:21481790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21481790 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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