| pubmed-article:21471523 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21471523 | lifeskim:mentions | umls-concept:C0019069 | lld:lifeskim |
| pubmed-article:21471523 | lifeskim:mentions | umls-concept:C0205082 | lld:lifeskim |
| pubmed-article:21471523 | lifeskim:mentions | umls-concept:C0376558 | lld:lifeskim |
| pubmed-article:21471523 | lifeskim:mentions | umls-concept:C0368953 | lld:lifeskim |
| pubmed-article:21471523 | lifeskim:mentions | umls-concept:C0021149 | lld:lifeskim |
| pubmed-article:21471523 | lifeskim:mentions | umls-concept:C0041700 | lld:lifeskim |
| pubmed-article:21471523 | pubmed:issue | 23 | lld:pubmed |
| pubmed-article:21471523 | pubmed:dateCreated | 2011-6-10 | lld:pubmed |
| pubmed-article:21471523 | pubmed:abstractText | The age-adjusted incidence of new factor VIII inhibitors was analyzed in all United Kingdom patients with severe hemophilia A between 1990 and 2009. Three hundred fifteen new inhibitors were reported to the National Hemophilia Database in 2528 patients with severe hemophilia who were followed up for a median (interquartile range) of 12 (4-19) years. One hundred sixty (51%) of these arose in patients ? 5 years of age after a median (interquartile range) of 6 (4-11) years' follow-up. The incidence of new inhibitors was 64.29 per 1000 treatment-years in patients < 5 years of age and 5.31 per 1000 treatment-years at age 10-49 years, rising significantly (P = .01) to 10.49 per 1000 treatment-years in patients more than 60 years of age. Factor VIII inhibitors arise in patients with hemophilia A throughout life with a bimodal risk, being greatest in early childhood and in old age. HIV was associated with significantly fewer new inhibitors. The inhibitor incidence rate ratio in HIV-seropositive patients was 0.32 times that observed in HIV-seronegative patients (P < .001). Further study is required to explore the natural history of later-onset factor VIII inhibitors and to investigate other potential risk factors for inhibitor development in previously treated patients. | lld:pubmed |
| pubmed-article:21471523 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471523 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21471523 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471523 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:21471523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471523 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21471523 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21471523 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:21471523 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:WilliamsMicha... | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:LiesnerRiR | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:CollinsPeter... | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:PalmerBenB | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:RangarajanSav... | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:ChalmersEliza... | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:HayCharles... | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:MacleanRhonaR | lld:pubmed |
| pubmed-article:21471523 | pubmed:author | pubmed-author:United... | lld:pubmed |
| pubmed-article:21471523 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21471523 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:21471523 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:21471523 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21471523 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21471523 | pubmed:pagination | 6367-70 | lld:pubmed |
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| pubmed-article:21471523 | pubmed:meshHeading | pubmed-meshheading:21471523... | lld:pubmed |
| pubmed-article:21471523 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21471523 | pubmed:articleTitle | Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom. | lld:pubmed |
| pubmed-article:21471523 | pubmed:affiliation | Manchester University Department of Haematology, Manchester Royal Infirmary, Manchester, UK. Charles.Hay@cmft.nhs.uk | lld:pubmed |
| pubmed-article:21471523 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21471523 | lld:pubmed |
