| pubmed-article:21466220 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C0029347 | lld:lifeskim |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C0022009 | lld:lifeskim |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C0456389 | lld:lifeskim |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C1705542 | lld:lifeskim |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:21466220 | lifeskim:mentions | umls-concept:C1549649 | lld:lifeskim |
| pubmed-article:21466220 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21466220 | pubmed:dateCreated | 2011-4-21 | lld:pubmed |
| pubmed-article:21466220 | pubmed:abstractText | Amantadine inhibits the M2 proton channel of influenza A virus, yet its clinical use has been limited by the rapid emergence of amantadine-resistant virus strains. We have synthesized and characterized a series of polycyclic compounds designed as ring-contracted or ring-expanded analogues of amantadine. Inhibition of the wild-type (wt) M2 channel and the A/M2-S31N and A/M2-V27A mutant ion channels were measured in Xenopus oocytes using two-electrode voltage clamp (TEV) assays. Several bisnoradamantane and noradamantane derivatives inhibited the wt ion channel. The compounds bind to a primary site delineated by Val27, Ala30, and Ser31, though ring expansion restricts the positioning in the binding site. Only the smallest analogue 8 was found to inhibit the S31N mutant ion channel. The structure-activity relationship obtained by TEV assay was confirmed by plaque reduction assays with A/H3N2 influenza virus carrying wt M2 protein. | lld:pubmed |
| pubmed-article:21466220 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21466220 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21466220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21466220 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21466220 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21466220 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:PintoLawrence... | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:LambRobert... | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:WangJunJ | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:NaesensLieveL | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:DeGradoWillia... | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:LuqueF... | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:VázquezSantia... | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:CampsPelayoP | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:MaChunlongC | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:DuqueMaría... | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:TorresEvaE | lld:pubmed |
| pubmed-article:21466220 | pubmed:author | pubmed-author:Juárez-Jiméne... | lld:pubmed |
| pubmed-article:21466220 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21466220 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:21466220 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:21466220 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21466220 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21466220 | pubmed:pagination | 2646-57 | lld:pubmed |
| pubmed-article:21466220 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:meshHeading | pubmed-meshheading:21466220... | lld:pubmed |
| pubmed-article:21466220 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21466220 | pubmed:articleTitle | Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus. | lld:pubmed |
| pubmed-article:21466220 | pubmed:affiliation | Laboratori de Qui?mica Farmace?utica (Unitat Associada al CSIC), Facultat de Farma?cia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Barcelona, Spain. | lld:pubmed |
| pubmed-article:21466220 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21466220 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21466220 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21466220 | lld:chembl |
