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pubmed-article:21456515pubmed:abstractTextA rapid approach to the spirocyclic core of cyclopamine was achieved in four steps from 2-pentenyl-furan. A furan Diels-Alder reaction followed by a one-pot dehalogenation/amination sequence provides the oxabicyclic triene that upon treatment with Grubbs' catalyst undergoes smooth rearrangement to the tricyclic core.lld:pubmed
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pubmed-article:21456515pubmed:articleTitleTandem metathesis reactions of oxabicyclo[2.2.1]heptenes: studies on the spirocyclic core of cyclopamine.lld:pubmed
pubmed-article:21456515pubmed:affiliationDepartment of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, United States.lld:pubmed
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