| pubmed-article:21440248 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C0812314 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C1705004 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C1518440 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:21440248 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:21440248 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21440248 | pubmed:dateCreated | 2011-4-14 | lld:pubmed |
| pubmed-article:21440248 | pubmed:abstractText | CD4(+) T cells play critical roles in the generation of protective immunity against a variety of pathogens. The main two types of effector CD4(+) T cells, Th1 and Th2 are characterized by their ability to produce signature cytokines. Among them, IL-10 is a multi-functional cytokine that plays a crucial role in maintaining the balance between immunity and tolerance. Although IL-10 is produced by both differentiated primary Th1 and Th2 cells, Th2 cells produce much higher levels of IL-10 upon stimulation. However, little information is available on the molecular mechanisms of IL-10 gene regulation at the transcriptional level. Interferon regulatory factor IRF4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4(+) T cells into Th2 cells. In this present study, we elucidate the underlying mechanism of IRF4 mediated IL-10 gene transcription in primary CD4(+) T cells. Th2 specific binding of IRF4 to the IRF4 responsive elements in IL-10 locus potentiated IL-10 expression in Th2 cells. Knockdown of IRF4 by siRNA decreased IL-10 expression level in Th2 cells. Nuclear translocation of IRF4 was much higher in Th2 cells upon stimulation, which contribute to maintain IL-10(high) phenotype of Th2 cells. Collectively, our results suggest that stimulation driven quantitative differences of IRF4 in the nucleus and its binding to IL-10 regulatory elements are crucial mechanisms to induce IL-10(high) gene expression in Th2 cells. | lld:pubmed |
| pubmed-article:21440248 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21440248 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21440248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21440248 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21440248 | pubmed:issn | 1090-2163 | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:ImSin-HyeogSH | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:LeeSung... | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:ParkZee... | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:HwangWonW | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:SoJae-SeonJS | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:KwonHo-KeunHK | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:LeeChoong-GuC... | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:SahooAnupamaA | lld:pubmed |
| pubmed-article:21440248 | pubmed:author | pubmed-author:MaengKi-EunKE | lld:pubmed |
| pubmed-article:21440248 | pubmed:copyrightInfo | 2011 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:21440248 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21440248 | pubmed:volume | 268 | lld:pubmed |
| pubmed-article:21440248 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21440248 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21440248 | pubmed:pagination | 97-104 | lld:pubmed |
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| pubmed-article:21440248 | pubmed:meshHeading | pubmed-meshheading:21440248... | lld:pubmed |
| pubmed-article:21440248 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21440248 | pubmed:articleTitle | IRF4 regulates IL-10 gene expression in CD4(+) T cells through differential nuclear translocation. | lld:pubmed |
| pubmed-article:21440248 | pubmed:affiliation | School of Life Sciences and Immune Synapse Research Center, Gwangju Institute of Science and Technology (GIST), Gwangju 500-712, Republic of Korea. | lld:pubmed |
| pubmed-article:21440248 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21440248 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21440248 | lld:entrezgene |
