| pubmed-article:21392990 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C0033607 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C0475370 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:21392990 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:21392990 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:21392990 | pubmed:dateCreated | 2011-4-4 | lld:pubmed |
| pubmed-article:21392990 | pubmed:abstractText | The human T cell leukemia/lymphotropic virus type 1 (HTLV-I) is clinically associated with adult T cell leukemia/lymphoma, HTLV-I associated myelopathy/tropical spastic paraparesis, and a number of other chronic inflammatory diseases. To stop the replication of the virus, we developed highly potent tetrapeptidic HTLV-I protease inhibitors. In a recent X-ray crystallography study, several of our inhibitors could not form co-crystal complexes with the protease due to their high hydrophobicity. In the current study, we designed, synthesized and evaluated the HTLV-I protease inhibition potency of compounds with hydrophilic end-capping moieties with the aim of improving pharmaceutic and pharmacokinetic properties. | lld:pubmed |
| pubmed-article:21392990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21392990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21392990 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21392990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21392990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21392990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21392990 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21392990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21392990 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21392990 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21392990 | pubmed:author | pubmed-author:KimuraTooruT | lld:pubmed |
| pubmed-article:21392990 | pubmed:author | pubmed-author:KisoYoshiakiY | lld:pubmed |
| pubmed-article:21392990 | pubmed:author | pubmed-author:KatoKeikoK | lld:pubmed |
| pubmed-article:21392990 | pubmed:author | pubmed-author:HidakaKoushiK | lld:pubmed |
| pubmed-article:21392990 | pubmed:author | pubmed-author:NguyenJeffrey... | lld:pubmed |
| pubmed-article:21392990 | pubmed:author | pubmed-author:KumadaHenri-O... | lld:pubmed |
| pubmed-article:21392990 | pubmed:copyrightInfo | Copyright © 2011 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21392990 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21392990 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:21392990 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21392990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21392990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21392990 | pubmed:pagination | 2425-9 | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:meshHeading | pubmed-meshheading:21392990... | lld:pubmed |
| pubmed-article:21392990 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21392990 | pubmed:articleTitle | Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles. | lld:pubmed |
| pubmed-article:21392990 | pubmed:affiliation | Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan. | lld:pubmed |
| pubmed-article:21392990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21392990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21392990 | lld:chembl |
