Linked Life Data

21388280

Source:http://linkedlifedata.com/resource/pubmed/id/21388280

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pubmed-article:21388280pubmed:abstractTextDamage to intestine is a serious problem after accidental radiation exposure. To examine substances to ameliorate damage by postirradiation administration, we focused on the regeneration process after irradiation of the intestine. Using experimental systems, the effects of clinically used sex hormones on regeneration were compared. An anabolic steroid, nandrolone (19-nortestosterone), stimulated proliferation in IEC-6 epithelial cells. A single injection of 19-nortestosterone ester with prolonged action into mice 24 h after abdominal irradiation at a lethal dose of 15.7 Gy showed significant life-saving effects. Regeneration indicators such as microcolonies of BrdU-incorporated cells at day 5 and c-myb mRNA expression levels at day 4 were enhanced by 19-nortestosterone administration. In contrast, high concentrations of estradiol inhibited growth of IEC-6 cells. Treatment of abdominally irradiated mice with estradiol ester decreased levels of regeneration indicators and survival. These results suggest the effectiveness of the anabolic steroid as well as the importance of manipulation of steroid receptors in the recovery of mucosa damaged by radiation.lld:pubmed
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pubmed-article:21388280pubmed:authorpubmed-author:IshiharaHiros...lld:pubmed
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pubmed-article:21388280pubmed:volume175lld:pubmed
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pubmed-article:21388280pubmed:year2011lld:pubmed
pubmed-article:21388280pubmed:articleTitleAcceleration of regeneration of mucosa in small intestine damaged by ionizing radiation using anabolic steroids.lld:pubmed
pubmed-article:21388280pubmed:affiliationMedical Treatment for High Dose Exposure Research Group, Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan. ishihara@nirs.go.jplld:pubmed
pubmed-article:21388280pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21388280pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed