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pubmed-article:21366807pubmed:abstractTextBone-destructive disease treatments include bisphosphonates and antibodies against receptor activator for nuclear factor ?B ligand (aRANKL). Osteonecrosis of the jaw (ONJ) is a side-effect. Aetiopathology models failed to explain their restriction to the jaw. The osteoproliferative transcription factor Msx-1 is expressed constitutively only in mature jaw bone. Msx-1 expression might be impaired in bisphosphonate-related ONJ. This study compared the expression of Msx-1, Bone Morphogenetic Protein (BMP)-2 and RANKL, in ONJ-affected and healthy jaw bone.lld:pubmed
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pubmed-article:21366807pubmed:copyrightInfo© 2011 John Wiley & Sons A/S.lld:pubmed
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pubmed-article:21366807pubmed:articleTitleMsx-1 is suppressed in bisphosphonate-exposed jaw bone analysis of bone turnover-related cell signalling after bisphosphonate treatment.lld:pubmed
pubmed-article:21366807pubmed:affiliationDepartment of Oral and Maxillofacial Surgery, University of Erlangen-Nuremberg, Erlangen, Germany. falk.wehrhan@uk-erlangen.delld:pubmed
pubmed-article:21366807pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21366807pubmed:publicationTypeComparative Studylld:pubmed
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