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pubmed-article:21343836pubmed:abstractTextPaclitaxel (PTX) is a useful treatment for peritoneal dissemination of malignant tumors. However, chemoresistance due to PTX-induced nuclear factor ?B (NF-?B) activation is an important cause of suboptimal therapeutic effect. We previously reported nafamostat mesilate (FUT175) inhibits NF-?B activation and promotes apoptosis in pancreatic cancer. We hypothesized that addition of FUT175 to PTX may enhance the antitumor effect in peritoneal dissemination of pancreatic cancer.lld:pubmed
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pubmed-article:21343836pubmed:articleTitleCombination paclitaxel and inhibitor of nuclear factor ?B activation improves therapeutic outcome for model mice with peritoneal dissemination of pancreatic cancer.lld:pubmed
pubmed-article:21343836pubmed:affiliationDepartment of Surgery, Institute of DNA Medicine, Jikei University School of Medicine, Minato-ku, Tokyo, Japan. sheetan@jikei.ac.jplld:pubmed
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