| pubmed-article:21337122 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21337122 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:21337122 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:21337122 | lifeskim:mentions | umls-concept:C0501384 | lld:lifeskim |
| pubmed-article:21337122 | lifeskim:mentions | umls-concept:C1512901 | lld:lifeskim |
| pubmed-article:21337122 | lifeskim:mentions | umls-concept:C0224394 | lld:lifeskim |
| pubmed-article:21337122 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:21337122 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21337122 | pubmed:dateCreated | 2011-3-24 | lld:pubmed |
| pubmed-article:21337122 | pubmed:abstractText | Interstitial cells of Cajal (ICC) have been shown to participate in nitrergic neurotransmission in various regions of the gastrointestinal (GI) tract. Recently, fibroblast-like cells, which are positive for platelet-derived growth factor receptor ? (PDGFR?(+)), have been suggested to participate additionally in inhibitory neurotransmission in the GI tract. The distribution of ICC and PDGFR?(+) cell populations and their relationship to inhibitory nerves within the mouse internal anal sphincter (IAS) are unknown. Immunohistochemical techniques and confocal microscopy were therefore used to examine the density and arrangement of ICC, PDGFR?(+) cells and neuronal nitric-oxide-synthase-positive (nNOS(+)) nerve fibers in the IAS of wild-type (WT) and W/W ( v ) mice. Of the total tissue volume within the IAS circular muscle layer, 18% consisted in highly branched PDGFR?(+) cells (PDGFR?(+)-IM). Other populations of PDGFR?(+) cells were observed within the submucosa and along the serosal and myenteric surfaces. Spindle-shaped intramuscular ICC (ICC-IM) were present in the WT mouse IAS but were largely absent from the W/W ( v ) IAS. The ICC-IM volume (5% of tissue volume) in the WT mouse IAS was significantly smaller than that of PDGFR?(+)-IM. Stellate-shaped submucosal ICC (ICC-SM) were observed in the WT and W/W ( v ) IAS. Minimum surface distance analysis revealed that nNOS(+) nerve fibers were closely aligned with both ICC-IM and PDGFR?(+)-IM. An even closer association was seen between ICC-IM and PDGFR?(+)-IM. Thus, a close morphological arrangement exists between inhibitory motor neurons, ICC-IM and PDGFR?(+)-IM suggesting that some functional interaction occurs between them contributing to inhibitory neurotransmission in the IAS. | lld:pubmed |
| pubmed-article:21337122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21337122 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21337122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21337122 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21337122 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21337122 | pubmed:issn | 1432-0878 | lld:pubmed |
| pubmed-article:21337122 | pubmed:author | pubmed-author:WardSean MSM | lld:pubmed |
| pubmed-article:21337122 | pubmed:author | pubmed-author:SandersKenton... | lld:pubmed |
| pubmed-article:21337122 | pubmed:author | pubmed-author:HennigGrant... | lld:pubmed |
| pubmed-article:21337122 | pubmed:author | pubmed-author:KurahashiMasa... | lld:pubmed |
| pubmed-article:21337122 | pubmed:author | pubmed-author:KeefKathleen... | lld:pubmed |
| pubmed-article:21337122 | pubmed:author | pubmed-author:CobineCarolin... | lld:pubmed |
| pubmed-article:21337122 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21337122 | pubmed:volume | 344 | lld:pubmed |
| pubmed-article:21337122 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21337122 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21337122 | pubmed:pagination | 17-30 | lld:pubmed |
| pubmed-article:21337122 | pubmed:dateRevised | 2011-10-13 | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:meshHeading | pubmed-meshheading:21337122... | lld:pubmed |
| pubmed-article:21337122 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21337122 | pubmed:articleTitle | Relationship between interstitial cells of Cajal, fibroblast-like cells and inhibitory motor nerves in the internal anal sphincter. | lld:pubmed |
| pubmed-article:21337122 | pubmed:affiliation | Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA. | lld:pubmed |
| pubmed-article:21337122 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21337122 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
