| pubmed-article:21330537 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21330537 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:21330537 | lifeskim:mentions | umls-concept:C0074512 | lld:lifeskim |
| pubmed-article:21330537 | lifeskim:mentions | umls-concept:C0444626 | lld:lifeskim |
| pubmed-article:21330537 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:21330537 | pubmed:issue | 6019 | lld:pubmed |
| pubmed-article:21330537 | pubmed:dateCreated | 2011-2-18 | lld:pubmed |
| pubmed-article:21330537 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:abstractText | Cotranslational targeting of membrane and secretory proteins is mediated by the universally conserved signal recognition particle (SRP). Together with its receptor (SR), SRP mediates the guanine triphosphate (GTP)-dependent delivery of translating ribosomes bearing signal sequences to translocons on the target membrane. Here, we present the crystal structure of the SRP:SR complex at 3.9 angstrom resolution and biochemical data revealing that the activated SRP:SR guanine triphosphatase (GTPase) complex binds the distal end of the SRP hairpin RNA where GTP hydrolysis is stimulated. Combined with previous findings, these results suggest that the SRP:SR GTPase complex initially assembles at the tetraloop end of the SRP RNA and then relocalizes to the opposite end of the RNA. This rearrangement provides a mechanism for coupling GTP hydrolysis to the handover of cargo to the translocon. | lld:pubmed |
| pubmed-article:21330537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21330537 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21330537 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21330537 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21330537 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:DoudnaJennife... | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:KeAilongA | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:BanNenadN | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:ShanShu-ouSO | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:AtaideSandro... | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:ShenKuangK | lld:pubmed |
| pubmed-article:21330537 | pubmed:author | pubmed-author:SchmitzNikola... | lld:pubmed |
| pubmed-article:21330537 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21330537 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:21330537 | pubmed:volume | 331 | lld:pubmed |
| pubmed-article:21330537 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21330537 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21330537 | pubmed:pagination | 881-6 | lld:pubmed |
| pubmed-article:21330537 | pubmed:dateRevised | 2011-10-18 | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:meshHeading | pubmed-meshheading:21330537... | lld:pubmed |
| pubmed-article:21330537 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21330537 | pubmed:articleTitle | The crystal structure of the signal recognition particle in complex with its receptor. | lld:pubmed |
| pubmed-article:21330537 | pubmed:affiliation | Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule Zurich (ETH Zurich), Zurich, Switzerland. | lld:pubmed |
| pubmed-article:21330537 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21330537 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:21330537 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:947978 | entrezgene:pubmed | pubmed-article:21330537 | lld:entrezgene |
| entrez-gene:947102 | entrezgene:pubmed | pubmed-article:21330537 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21330537 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21330537 | lld:entrezgene |
