| pubmed-article:2132822 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2132822 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2132822 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:2132822 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:2132822 | lifeskim:mentions | umls-concept:C0007584 | lld:lifeskim |
| pubmed-article:2132822 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2132822 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:2132822 | pubmed:dateCreated | 1992-2-18 | lld:pubmed |
| pubmed-article:2132822 | pubmed:abstractText | In the developing brain, neurons are derived from multipotential precursor cells in a precise sequence, where the time when a neuron becomes postmitotic is closely linked to the differentiated function of the neuron. Work from our group (1) identifies the Nes+ neuronal precursor state, (2) defines growth factors that regulate the proliferation of Nes+ precursor cells and their differentiation into neurons, and (3) establishes immortal cell lines that may be useful models for the terminal differentiation of Nes+ cells into neurons and astrocytes. These results suggest that the basic technical requirements are now in place to define the signals that control the transition from a precursor cell to a postmitotic neuron in the mammalian CNS. Control of this terminal differentiation is a key step in generating the large numbers and types of cells in the CNS. | lld:pubmed |
| pubmed-article:2132822 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2132822 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2132822 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2132822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2132822 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2132822 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2132822 | pubmed:issn | 0091-7451 | lld:pubmed |
| pubmed-article:2132822 | pubmed:author | pubmed-author:McKayRR | lld:pubmed |
| pubmed-article:2132822 | pubmed:author | pubmed-author:CunninghamMM | lld:pubmed |
| pubmed-article:2132822 | pubmed:author | pubmed-author:HayesTT | lld:pubmed |
| pubmed-article:2132822 | pubmed:author | pubmed-author:ValtzNN | lld:pubmed |
| pubmed-article:2132822 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2132822 | pubmed:volume | 55 | lld:pubmed |
| pubmed-article:2132822 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2132822 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2132822 | pubmed:pagination | 291-301 | lld:pubmed |
| pubmed-article:2132822 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:meshHeading | pubmed-meshheading:2132822-... | lld:pubmed |
| pubmed-article:2132822 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2132822 | pubmed:articleTitle | Mechanisms regulating cell number and type in the mammalian central nervous system. | lld:pubmed |
| pubmed-article:2132822 | pubmed:affiliation | Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge 02139. | lld:pubmed |
| pubmed-article:2132822 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2132822 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2132822 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
