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pubmed-article:21315817pubmed:dateCreated2011-6-6lld:pubmed
pubmed-article:21315817pubmed:abstractTextThe ability to conduct weight-of-evidence assessments to inform the evaluation of potential environmental neurotoxicants is limited by lack of comparability of study methods, data analysis, and reporting. There is a need to establish consensus guidelines for conducting, analyzing, and reporting neurodevelopmental environmental epidemiologic studies, while recognizing that consistency is likewise needed for epidemiology studies examining other health outcomes. This paper proposes a set of considerations to be used by the scientific community at-large as a tool for systematically evaluating the quality of proposed and/or published studies in terms of their value for weight-of-evidence assessments. Particular emphasis is placed on evaluating factors influencing the risk of incorrect conclusions at the level of study findings. The proposed considerations are the first step in what must be a larger consensus-based process and can serve to catalyze such a discussion. Achieving consensus in these types of endeavors is difficult; however, opportunities exist for further interdisciplinary discussion, collaboration, and research that will help realize this goal. Broad acceptance and application of such an approach can facilitate the expanded use of environmental epidemiology studies of potential neurodevelopmental toxicants in the protection of public health, and specifically children's health.lld:pubmed
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pubmed-article:21315817pubmed:authorpubmed-author:GoodmanMichae...lld:pubmed
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pubmed-article:21315817pubmed:authorpubmed-author:AnthonyLaura...lld:pubmed
pubmed-article:21315817pubmed:copyrightInfoCopyright © 2011 Elsevier Inc. All rights reserved.lld:pubmed
pubmed-article:21315817pubmed:issnTypeElectroniclld:pubmed
pubmed-article:21315817pubmed:volume33lld:pubmed
pubmed-article:21315817pubmed:ownerNLMlld:pubmed
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pubmed-article:21315817pubmed:pagination354-9lld:pubmed
pubmed-article:21315817pubmed:dateRevised2011-9-29lld:pubmed
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pubmed-article:21315817pubmed:articleTitleA proposal to facilitate weight-of-evidence assessments: Harmonization of Neurodevelopmental Environmental Epidemiology Studies (HONEES).lld:pubmed
pubmed-article:21315817pubmed:affiliationDepartments of Psychology and Psychiatry, University of North Carolina at Chapel Hill/Davie Hall, University of North Carolina, Chapel Hill, NC 27599, USA.lld:pubmed
pubmed-article:21315817pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21315817pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed