| pubmed-article:21306483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C0014665 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C0019944 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C2608085 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C1824884 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:21306483 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:21306483 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:21306483 | pubmed:dateCreated | 2011-3-23 | lld:pubmed |
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| pubmed-article:21306483 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21306483 | pubmed:abstractText | The endotheliotropism of equine herpesvirus-1 (EHV-1) leads to encephalomyelitis secondary to vasculitis and thrombosis in the infected horse central nervous system (CNS). To identify the host factors involved in EHV-1 infection of CNS endothelial cells, we performed functional cloning using an equine brain microvascular endothelial cell cDNA library. Exogenous expression of equine major histocompatibility complex (MHC) class I heavy chain genes conferred susceptibility to EHV-1 infection in mouse NIH3T3 cells, which are not naturally susceptible to EHV-1 infection. Equine MHC class I molecules bound to EHV-1 glycoprotein D (gD), and both anti-gD antibodies and a soluble form of gD blocked viral entry into NIH3T3 cells stably expressing the equine MHC class I heavy chain gene (3T3-A68 cells). Treatment with an anti-equine MHC class I monoclonal antibody blocked EHV-1 entry into 3T3-A68 cells, equine dermis (E. Derm) cells and equine brain microvascular endothelial cells. In addition, inhibition of cell surface expression of MHC class I molecules in E. Derm cells drastically reduced their susceptibility to EHV-1 infection. These results suggest that equine MHC class I is a functional gD receptor that plays a pivotal role in EHV-1 entry into equine cells. | lld:pubmed |
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| pubmed-article:21306483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21306483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21306483 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21306483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21306483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21306483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21306483 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:21306483 | pubmed:issn | 1365-2443 | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:OkamotoMinoru... | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:TaniyamaHiroy... | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:SawaHirofumiH | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:KimuraTakashi... | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:FukushiHideto... | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:MakinoYoshino... | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:HasebeRieR | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:MatsudaKazuya... | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:SuzukiTadakiT | lld:pubmed |
| pubmed-article:21306483 | pubmed:author | pubmed-author:SasakiMichihi... | lld:pubmed |
| pubmed-article:21306483 | pubmed:copyrightInfo | © 2011 The Authors. Journal compilation © 2011 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd. | lld:pubmed |
| pubmed-article:21306483 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21306483 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:21306483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21306483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21306483 | pubmed:pagination | 343-57 | lld:pubmed |
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| pubmed-article:21306483 | pubmed:year | 2011 | lld:pubmed |
