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pubmed-article:2128472pubmed:abstractTextA total of 311 patients presenting with uncomplicated gonorrhoea were entered into a comparative randomized open-label study and given single-dose treatment with either oral cefuroxime axetil (CAE) or intramuscular procaine penicillin (PP). Neisseria gonorrhoeae was eliminated from 129 (98%) of 131 evaluable patients treated with CAE and 127 (98%) of 129 evaluable patients treated with PP. None of the 4 treatment failures (3 male and 1 female) were caused by beta-lactamase-producing isolates. Both treatments were well tolerated with minor adverse events reported in 3 (2%) of CAE treated patients. We conclude that CAE is an effective, well tolerated treatment for uncomplicated gonorrhoea which has the convenience and acceptability of single-dose oral therapy.lld:pubmed
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pubmed-article:2128472pubmed:dateRevised2009-11-19lld:pubmed
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pubmed-article:2128472pubmed:articleTitleComparative study of cefuroxime axetil and procaine penicillin in the treatment of uncomplicated gonorrhoea.lld:pubmed
pubmed-article:2128472pubmed:affiliationDepartment of Genitourinary Medicine, Royal Hallamshire Hospital, Sheffield, UK.lld:pubmed
pubmed-article:2128472pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2128472pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:2128472pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:2128472pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:2128472pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed