| pubmed-article:21280982 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C0625647 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C0007137 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:21280982 | lifeskim:mentions | umls-concept:C1521805 | lld:lifeskim |
| pubmed-article:21280982 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21280982 | pubmed:dateCreated | 2011-2-14 | lld:pubmed |
| pubmed-article:21280982 | pubmed:abstractText | The objective of this study was to investigate the impact of human beta-defensins (hBDs) on oral squamous cell carcinoma (OSCC) proliferation and hBD expression in vitro. BHY-OSCC cell lines were stimulated with hBD-1, -2, and -3. Proliferation of BHY cells was ascertained and hBD-mRNA expression was evaluated by real-time PCR. Proliferation of BHY cells decreased by 25% in response to hBD-1 stimulation but increased after stimulation with hBD-2 and -3. HBD-1 stimulation enhanced hBD-3 expression, whereas HBD-2 stimulation decreased early hBD-3 expression. HBD-3 stimulation enhanced hBD-1 expression. HBDs profoundly impact on OSCC proliferation and hBD expression in vitro. Therefore, hBD-1 might function as a tumor suppressor gene in OSCCs, while hBD-2 and -3 might be protooncogenes. | lld:pubmed |
| pubmed-article:21280982 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21280982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280982 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21280982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21280982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21280982 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:21280982 | pubmed:issn | 1532-4192 | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:NovakNatalija... | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:WinterJochenJ | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:WenghoeferMat... | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:AllamJean-Pie... | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:MartiniMarkus... | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:PantelisAnnet... | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:JepsenSoerenS | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:ReichRudolfR | lld:pubmed |
| pubmed-article:21280982 | pubmed:author | pubmed-author:KrausDominikD | lld:pubmed |
| pubmed-article:21280982 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21280982 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:21280982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21280982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21280982 | pubmed:pagination | 196-201 | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:meshHeading | pubmed-meshheading:21280982... | lld:pubmed |
| pubmed-article:21280982 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21280982 | pubmed:articleTitle | Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation. | lld:pubmed |
| pubmed-article:21280982 | pubmed:affiliation | Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany. | lld:pubmed |
| pubmed-article:21280982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21280982 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21280982 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21280982 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:21280982 | lld:entrezgene |
