Linked Life Data

21274552

Source:http://linkedlifedata.com/resource/pubmed/id/21274552

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pubmed-article:21274552pubmed:abstractTextPairing of the sex chromosomes during mammalian meiosis is characterized by the formation of a unique heterochromatin structure at the XY body. The mechanisms underlying the formation of this nuclear domain are reportedly highly conserved from marsupials to mammals. In this study, we demonstrate that in contrast to all eutherian species studied to date, partial synapsis of the heterologous sex chromosomes during pachytene stage in the horse is not associated with the formation of a typical macrochromatin domain at the XY body. While phosphorylated histone H2AX (?H2AX) and macroH2A1.2 are present as a diffuse signal over the entire macrochromatin domain in mouse pachytene spermatocytes, ?H2AX, macroH2A1.2, and the cohesin subunit SMC3 are preferentially enriched at meiotic sex chromosome cores in equine spermatocytes. Moreover, although several histone modifications associated with this nuclear domain in the mouse such as H3K4me2 and ubH2A are conspicuously absent in the equine XY body, prominent RNA polymerase II foci persist at the sex chromosomes. Thus, the localization of key marker proteins and histone modifications associated with the XY body in the horse differs significantly from all other mammalian systems described. These results demonstrate that the epigenetic landscape and heterochromatinization of the equine XY body might be regulated by alternative mechanisms and that some features of XY body formation may be evolutionary divergent in the domestic horse. We propose equine spermatogenesis as a unique model system for the study of the regulatory networks leading to the epigenetic control of gene expression during XY body formation.lld:pubmed
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pubmed-article:21274552pubmed:authorpubmed-author:DalyChristoph...lld:pubmed
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pubmed-article:21274552pubmed:volume120lld:pubmed
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pubmed-article:21274552pubmed:pagination227-44lld:pubmed
pubmed-article:21274552pubmed:dateRevised2011-9-26lld:pubmed
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pubmed-article:21274552pubmed:year2011lld:pubmed
pubmed-article:21274552pubmed:articleTitleChromatin configuration and epigenetic landscape at the sex chromosome bivalent during equine spermatogenesis.lld:pubmed
pubmed-article:21274552pubmed:affiliationFemale Germ Cell Biology Group, Department of Clinical Studies, University of Pennsylvania, New Bolton Center, Kennett Square, PA 19348, USA.lld:pubmed
pubmed-article:21274552pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:21274552pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:21274552pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed