| pubmed-article:21236687 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21236687 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:21236687 | lifeskim:mentions | umls-concept:C0024117 | lld:lifeskim |
| pubmed-article:21236687 | lifeskim:mentions | umls-concept:C0004048 | lld:lifeskim |
| pubmed-article:21236687 | lifeskim:mentions | umls-concept:C1150571 | lld:lifeskim |
| pubmed-article:21236687 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:21236687 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:21236687 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:21236687 | pubmed:dateCreated | 2011-2-1 | lld:pubmed |
| pubmed-article:21236687 | pubmed:abstractText | Installation of sites for metabolism in the lead compound PHA-767408 was the key focus of the IKK-2 inhaled program. This paper reports our efforts to identify a novel series of aminopyridinecarboxamide-based IKK-2 inhibitors, which display low nanomolar potency against IKK-2 with long duration of action (DOA), and metabolically labile to phase I and/or phase II metabolizing enzymes with potential capability for multiple routes of clearance. Several compounds have demonstrated their potential usefulness in the treatment of asthma and chronic obstructive pulmonary disease (COPD). | lld:pubmed |
| pubmed-article:21236687 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21236687 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21236687 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21236687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21236687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21236687 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21236687 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21236687 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21236687 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:MathialaganSu... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:XiongLiL | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:HuYidingY | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:TUIP CPC | lld:pubmed |
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| pubmed-article:21236687 | pubmed:author | pubmed-author:RedingMatthew... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:ChristineLori... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:HuangHorng-Ch... | lld:pubmed |
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| pubmed-article:21236687 | pubmed:author | pubmed-author:BonarSheri... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:VenkatramanNe... | lld:pubmed |
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| pubmed-article:21236687 | pubmed:author | pubmed-author:LennonPatrick... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:WolfsonSerge... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:BrustkernSara... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:ChenNatalie... | lld:pubmed |
| pubmed-article:21236687 | pubmed:author | pubmed-author:HeierRichard... | lld:pubmed |
| pubmed-article:21236687 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:21236687 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21236687 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21236687 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:21236687 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21236687 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21236687 | pubmed:pagination | 1242-55 | lld:pubmed |
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| pubmed-article:21236687 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21236687 | pubmed:articleTitle | Aminopyridinecarboxamide-based inhaled IKK-2 inhibitors for asthma and COPD: Structure-activity relationship. | lld:pubmed |
| pubmed-article:21236687 | pubmed:affiliation | Department of Medicinal Chemistry, Pfizer Inc., 700 Chesterfield Parkway West, St. Louis, MO 63017, USA. jin.xie@pfizer.com | lld:pubmed |
| pubmed-article:21236687 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21236687 | lld:chembl |
