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pubmed-article:2117971pubmed:abstractTextA case of uveal malignant melanoma and contralateral optic nerve glioma is described in a 53-year-old Caucasian male with multiple uveal melanocytic hamartomas and neurofibromatosis. The eye was enucleated, and histologically the melanoma was found to consist of 70% epithelioid cells, with many bizarre, multinucleated forms. CT scan demonstrated a non-enhancing, fusiform enlargement of the contralateral optic nerve with enlargement of the optic canal and intracranial extension. This combination of tumours has not previously been reported in a patient with neurofibromatosis and serves to emphasise the common neuroectodermal origin of tumours in this autosomal dominant condition.lld:pubmed
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pubmed-article:2117971pubmed:articleTitleUveal malignant melanoma and optic nerve glioma in von Recklinghausen's neurofibromatosis.lld:pubmed
pubmed-article:2117971pubmed:affiliationDepartment of Pathology, Vancouver General Hospital, British Columbia, Canada.lld:pubmed
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