| pubmed-article:21122567 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21122567 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:21122567 | lifeskim:mentions | umls-concept:C0004482 | lld:lifeskim |
| pubmed-article:21122567 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:21122567 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:21122567 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:21122567 | pubmed:dateCreated | 2010-12-2 | lld:pubmed |
| pubmed-article:21122567 | pubmed:abstractText | Azathioprine is a thiopurine immunosuppressive antimetabolite used to chronically treat inflammatory bowel disease and autoimmune hepatitis. Azathioprine treatment is a long-term therapy and therefore it is at risk for non-adherence, which is considered an important determinant of treatment inefficacy. Measurement of 6-thioguanine and 6-methylmercaptopurine nucleotides has been recently suggested as a screener for non-adherence detection. We describe four young patients in which non-adherence to azathioprine therapy was detected only through the measurement of drug metabolite concentrations, and the criterion for non-adherence was undetectable metabolite levels. After the identification of non-adherence, patients and their families were approached and the importance of a correct drug administration was thoroughly enlightened and discussed; this allowed obtaining a full remission in all subjects. Our observations support the use of undetectable metabolite levels as indicators of non-adherence to therapy in azathioprine treated patients. The additional level of medical supervision given by this assay allows getting a better adherence to medical treatment, which results in an improvement in the response to therapy; these benefits may justify the costs associated with the assay. | lld:pubmed |
| pubmed-article:21122567 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21122567 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21122567 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21122567 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:21122567 | pubmed:issn | 1876-4479 | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:DecortiGiulia... | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:VenturaAlessa... | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:BartoliFioraF | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:MartelossiSte... | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:StoccoGabriel... | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:CampanozziAng... | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:MarinoSaraS | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:LonderoMarghe... | lld:pubmed |
| pubmed-article:21122567 | pubmed:author | pubmed-author:MalusaNoeliaN | lld:pubmed |
| pubmed-article:21122567 | pubmed:copyrightInfo | Copyright © 2010 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:21122567 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21122567 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:21122567 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21122567 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21122567 | pubmed:pagination | 599-602 | lld:pubmed |
| pubmed-article:21122567 | pubmed:meshHeading | pubmed-meshheading:21122567... | lld:pubmed |
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| pubmed-article:21122567 | pubmed:meshHeading | pubmed-meshheading:21122567... | lld:pubmed |
| pubmed-article:21122567 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21122567 | pubmed:articleTitle | Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence. | lld:pubmed |
| pubmed-article:21122567 | pubmed:affiliation | Department of Life Sciences, University of Trieste, Italy. | lld:pubmed |
| pubmed-article:21122567 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21122567 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:21122567 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
