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pubmed-article:21106952pubmed:abstractTextthrombolytic treatment with tissue plasminogen activator (tPA) improves outcome of patients with stroke who can be treated within 3 hours of symptom onset. However, delayed treatment with tPA leads to increased risk of hemorrhagic transformation and can result in enhanced brain injury. The purpose of this study is to validate a reproducible mouse model of hemorrhagic transformation associated with delayed administration of tPA.lld:pubmed
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pubmed-article:21106952pubmed:articleTitleA mouse model of hemorrhagic transformation by delayed tissue plasminogen activator administration after in situ thromboembolic stroke.lld:pubmed
pubmed-article:21106952pubmed:affiliationDepartamento de Farmacología. Facultad de Medicina, Universidad Complutense Madrid, 28040, Madrid, Spain.lld:pubmed
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