| pubmed-article:21078213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C1121571 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0010467 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:21078213 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:21078213 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21078213 | pubmed:dateCreated | 2011-1-10 | lld:pubmed |
| pubmed-article:21078213 | pubmed:abstractText | Paraoxonase 1 (PON1) is an enzyme that is mainly synthesised in the liver and protects LDL from oxidation, thereby exhibiting antiatherogenic properties. Using a luciferase reporter gene assay, we tested curcumin for its ability to induce PON1 in Huh7 hepatocytes in culture. Curcumin ( ? 10 ?mol/l) dose-dependently induced PON1 transactivation in Huh7 cells. However, dietary supplementation of female B6C3F1 mice with curcumin (500 mg/kg diet) for 2 weeks did not increase the hepatic PON1 mRNA and protein levels. No curcumin was detectable in the plasma of the 12 h fasted mice. In conclusion, curcumin may be a potent PON1 inducer in cultured cells in vitro, but not in the liver of curcumin-fed mice because of its low concentrations in vivo. | lld:pubmed |
| pubmed-article:21078213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21078213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21078213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21078213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21078213 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21078213 | pubmed:issn | 1475-2662 | lld:pubmed |
| pubmed-article:21078213 | pubmed:author | pubmed-author:RimbachGerald... | lld:pubmed |
| pubmed-article:21078213 | pubmed:author | pubmed-author:FrankJanJ | lld:pubmed |
| pubmed-article:21078213 | pubmed:author | pubmed-author:SchraderCharl... | lld:pubmed |
| pubmed-article:21078213 | pubmed:author | pubmed-author:SchiborrChris... | lld:pubmed |
| pubmed-article:21078213 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21078213 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:21078213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21078213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21078213 | pubmed:pagination | 167-70 | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:meshHeading | pubmed-meshheading:21078213... | lld:pubmed |
| pubmed-article:21078213 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21078213 | pubmed:articleTitle | Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo. | lld:pubmed |
| pubmed-article:21078213 | pubmed:affiliation | Institute of Human Nutrition and Food Science, Christian-Albrechts-University of Kiel, Hermann-Rodewald-Street 6, 24118 Kiel, Germany. | lld:pubmed |
| pubmed-article:21078213 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21078213 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:21078213 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
