Linked Life Data

2107121

Source:http://linkedlifedata.com/resource/pubmed/id/2107121

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pubmed-article:2107121pubmed:abstractTextThe Alcohol dehydrogenase (Adh) genes of two distantly related species, Drosophila melanogaster and Drosophila mulleri, display similar, but not identical, patterns of tissue-specific expression in larvae and adults. The regulatory DNA sequences necessary for wild-type Adh expression in D. mulleri larvae were previously reported. In this paper we present an analysis of the DNA sequences necessary for wild-type Adh expression in D. melanogaster larvae. We show that transcription from the proximal promoter of the melanogaster Adh gene is regulated by a far upstream enhancer and two or more elements near the transcription start site. The enhancer is tissue specific and stimulates transcription to high levels in fat body and to lower levels in midgut and malpighian tubules whether linked to the proximal promoter or to a heterologous promoter. The enhancer activity localized to at least two discrete regions dispersed over more than 1.7 kb of DNA. Deletion of any one of these subregions reduces Adh transcription in all three larval tissues. Similarly, two regions immediately upstream of the proximal promoter start site are necessary for wild-type transcription levels in all three tissues. Thus, each of the identified regulatory elements is sufficient for low levels of Adh gene expression in all three larval tissues, but maximal levels of expression requires the entire set.lld:pubmed
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pubmed-article:2107121pubmed:articleTitleIdentification of cis-regulatory elements required for larval expression of the Drosophila melanogaster alcohol dehydrogenase gene.lld:pubmed
pubmed-article:2107121pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.lld:pubmed
pubmed-article:2107121pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2107121pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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