| pubmed-article:2104959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C0043167 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C0040661 | lld:lifeskim |
| pubmed-article:2104959 | lifeskim:mentions | umls-concept:C1705162 | lld:lifeskim |
| pubmed-article:2104959 | pubmed:issue | 6253 | lld:pubmed |
| pubmed-article:2104959 | pubmed:dateCreated | 1990-2-21 | lld:pubmed |
| pubmed-article:2104959 | pubmed:abstractText | Receptors stimulating phospholipase C do so through heterotrimeric GTP-binding proteins to produce two second messengers, inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol. In spite of the detailed understanding of phospholipase C structure and phosphatidyl inositol signalling, the identity of the GTP-binding protein involved is so far unknown. To address this issue, we have used the Xenopus oocyte in which muscarinic receptors couple to phospholipase C through a pertussis toxin-sensitive GTP-binding protein. In this cell, InsP3 mobilizes intracellular Ca2+ to evoke a Cl- current. The magnitude of this Cl- current is proportional to the amount of InsP3 in the cell, and therefore can be used as an assay for InsP3 production. We report here that the activated alpha-subunit of the GTP-binding protein GO, when directly injected into oocytes, evokes a Cl- current by mobilizing Ca2+ from intracellular InsP3-sensitive stores. We also show that holo-GO, when injected into oocytes, can specifically enhance the muscarinic receptor-stimulated Cl- current. These data indicate that GO can serve as the signal transducer of the receptor-regulated phospholipase C in Xenopus oocytes. | lld:pubmed |
| pubmed-article:2104959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2104959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2104959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2104959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2104959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2104959 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:2104959 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2104959 | pubmed:author | pubmed-author:LandauE MEM | lld:pubmed |
| pubmed-article:2104959 | pubmed:author | pubmed-author:IyengarRR | lld:pubmed |
| pubmed-article:2104959 | pubmed:author | pubmed-author:POTHAA | lld:pubmed |
| pubmed-article:2104959 | pubmed:author | pubmed-author:CartyD JDJ | lld:pubmed |
| pubmed-article:2104959 | pubmed:author | pubmed-author:MoriartyT MTM | lld:pubmed |
| pubmed-article:2104959 | pubmed:author | pubmed-author:PadrellEE | lld:pubmed |
| pubmed-article:2104959 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2104959 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:2104959 | pubmed:volume | 343 | lld:pubmed |
| pubmed-article:2104959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2104959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2104959 | pubmed:pagination | 79-82 | lld:pubmed |
| pubmed-article:2104959 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:2104959 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:2104959 | pubmed:articleTitle | Go protein as signal transducer in the pertussis toxin-sensitive phosphatidylinositol pathway. | lld:pubmed |
| pubmed-article:2104959 | pubmed:affiliation | Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029. | lld:pubmed |
| pubmed-article:2104959 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2104959 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2104959 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2104959 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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