| pubmed-article:21041494 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C1521751 | lld:lifeskim |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C0227276 | lld:lifeskim |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C0057256 | lld:lifeskim |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C0033799 | lld:lifeskim |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:21041494 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:21041494 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21041494 | pubmed:dateCreated | 2010-12-23 | lld:pubmed |
| pubmed-article:21041494 | pubmed:abstractText | Paneth cells at the base of small intestinal crypts secrete microbicidal ?-defensins, termed cryptdins (Crps) in mice, as mediators of innate immunity. Proteomic studies show that five abundant Paneth cell ?-defensins in C57BL/6 mice are strain specific in that they have not been identified in other inbred strains of mice. Two C57BL/6-specific peptides are coded for by the Defcr20 and -21 genes evident in the NIH C57BL/6 genome but absent from the Celera mixed-strain assembly, which excludes C57BL/6 data and differs from the NIH build with respect to the organization of the ?-defensin gene locus. Conversely, C57BL/6 mice lack the Crp1, -2, -4, and -6 peptides and their corresponding Defcr1, -2, -4, and -6 genes, which are common to several mouse strains, including those of the Celera assembly. In C57BL/6 mice, ?-defensin gene diversification appears to have occurred by tandem duplication of a multigene cassette that was not found in the mixed-strain assembly. Both mouse genome assemblies contain conserved ?-defensin pseudogenes that are closely related to functional myeloid ?-defensin genes in the rat, suggesting that the neutrophil ?-defensin defect in mice resulted from progressive gene loss. Given the role of ?-defensins in shaping the composition of the enteric microflora, such polymorphisms may influence outcomes in mouse models of disease or infection. | lld:pubmed |
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| pubmed-article:21041494 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21041494 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041494 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21041494 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21041494 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21041494 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21041494 | pubmed:issn | 1098-5522 | lld:pubmed |
| pubmed-article:21041494 | pubmed:author | pubmed-author:TanabeHirokiH | lld:pubmed |
| pubmed-article:21041494 | pubmed:author | pubmed-author:OuelletteAndr... | lld:pubmed |
| pubmed-article:21041494 | pubmed:author | pubmed-author:ShanahanMicha... | lld:pubmed |
| pubmed-article:21041494 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21041494 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:21041494 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21041494 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21041494 | pubmed:pagination | 459-73 | lld:pubmed |
| pubmed-article:21041494 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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