| pubmed-article:21037556 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0664336 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0142963 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0599894 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:21037556 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:21037556 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:21037556 | pubmed:dateCreated | 2011-1-19 | lld:pubmed |
| pubmed-article:21037556 | pubmed:abstractText | To test the feasibility of using the survivin promoter to induce specific expression of sodium/iodide symporter (NIS) in cancer cell lines and tumors for targeted use of radionuclide therapy, a recombinant adenovirus, Ad-SUR-NIS, that expressed the NIS gene under control of the survivin promoter was constructed. Ad-SUR-NIS mediating iodide uptake and cytotoxicity was performed in vitro. Scintigraphic, biodistribution and radioiodine therapy studies were performed in vivo. PC-3 (prostate); HepG2 (hepatoma) and A375 (melanoma) cancer cells all exhibited perchlorate-sensitive iodide uptake after infection with Ad-SUR-NIS, approximately 50 times higher than that of negative control Ad-CMV-GFP-infected cells. No significant iodide uptake was observed in normal human dental pulp fibroblast (DPF) cells after infection with Ad-SUR-NIS. Clonogenic assays demonstrated that Ad-SUR-NIS-infected cancer cells were selectively killed by exposure to (131)I. Ad-SUR-NIS-infected tumors show significant radioiodine accumulation (13.3 ± 2.85% ID per g at 2 h post-injection), and the effective half-life was 3.1 h. Moreover, infection with Ad-SUR-NIS in combination with (131)I suppressed tumor growth. These results indicate that expression of NIS under control of the survivin promoter can likely be used to achieve cancer-specific expression of NIS in many types of cancers. In combination with radioiodine therapy, this strategy is a possible method of cancer gene therapy. | lld:pubmed |
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| pubmed-article:21037556 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21037556 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21037556 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21037556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21037556 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:21037556 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21037556 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:21037556 | pubmed:issn | 1476-5500 | lld:pubmed |
| pubmed-article:21037556 | pubmed:author | pubmed-author:LUGG | lld:pubmed |
| pubmed-article:21037556 | pubmed:author | pubmed-author:ONOS ISI | lld:pubmed |
| pubmed-article:21037556 | pubmed:author | pubmed-author:HuantEE | lld:pubmed |
| pubmed-article:21037556 | pubmed:author | pubmed-author:ZhaoZZ | lld:pubmed |
| pubmed-article:21037556 | pubmed:author | pubmed-author:KuangAA | lld:pubmed |
| pubmed-article:21037556 | pubmed:author | pubmed-author:GoodNN | lld:pubmed |
| pubmed-article:21037556 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21037556 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:21037556 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21037556 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21037556 | pubmed:pagination | 144-52 | lld:pubmed |
| pubmed-article:21037556 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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| pubmed-article:21037556 | pubmed:meshHeading | pubmed-meshheading:21037556... | lld:pubmed |
| pubmed-article:21037556 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21037556 | pubmed:articleTitle | Targeting of tumor radioiodine therapy by expression of the sodium iodide symporter under control of the survivin promoter. | lld:pubmed |
| pubmed-article:21037556 | pubmed:affiliation | Department of Nuclear Medicine, National Key Discipline of Medical Imaging and Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China. | lld:pubmed |
| pubmed-article:21037556 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21037556 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
