| pubmed-article:21028889 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21028889 | lifeskim:mentions | umls-concept:C0004611 | lld:lifeskim |
| pubmed-article:21028889 | lifeskim:mentions | umls-concept:C2350017 | lld:lifeskim |
| pubmed-article:21028889 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:21028889 | lifeskim:mentions | umls-concept:C1704638 | lld:lifeskim |
| pubmed-article:21028889 | lifeskim:mentions | umls-concept:C0330095 | lld:lifeskim |
| pubmed-article:21028889 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:21028889 | pubmed:dateCreated | 2010-11-29 | lld:pubmed |
| pubmed-article:21028889 | pubmed:abstractText | The cone snail Conus pulicarius from the Philippines provides a specific habitat for actinomycetes and other bacteria. A phenotypic screen using primary cultures of mouse dorsal root ganglion neurons revealed that one C. pulicarius associate, Streptomyces sp. CP32, produces a series of natural products that enhance or diminish whole-cell Ca(2+) flux. These compounds include known thiazoline compounds and a series of new derivatives, pulicatins A-E (6-10). Individual compounds were shown to bind to a series of human receptors, with selective binding to the human serotonin 5-HT(2B) receptor. Here, we report the structure elucidation of the new compounds and results of the neurological assays. | lld:pubmed |
| pubmed-article:21028889 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21028889 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21028889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21028889 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21028889 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:21028889 | pubmed:issn | 1520-6025 | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:OliveraBaldom... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:ConcepcionGis... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:HaygoodMargo... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:PeraudOlivier... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:SchmidtEric... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:AntemanoRowen... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:HughenRonald... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:LinZhenjianZ | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:TianeroMa... | lld:pubmed |
| pubmed-article:21028889 | pubmed:author | pubmed-author:LightAlanA | lld:pubmed |
| pubmed-article:21028889 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21028889 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:21028889 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:21028889 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21028889 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21028889 | pubmed:pagination | 1922-6 | lld:pubmed |
| pubmed-article:21028889 | pubmed:dateRevised | 2011-10-6 | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:meshHeading | pubmed-meshheading:21028889... | lld:pubmed |
| pubmed-article:21028889 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:21028889 | pubmed:articleTitle | Pulicatins A-E, neuroactive thiazoline metabolites from cone snail-associated bacteria. | lld:pubmed |
| pubmed-article:21028889 | pubmed:affiliation | Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States. | lld:pubmed |
| pubmed-article:21028889 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:21028889 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21028889 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:21028889 | lld:pubmed |
