| pubmed-article:20956305 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C0040845 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C0033414 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C1416962 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C0450131 | lld:lifeskim |
| pubmed-article:20956305 | lifeskim:mentions | umls-concept:C2926735 | lld:lifeskim |
| pubmed-article:20956305 | pubmed:issue | 44 | lld:pubmed |
| pubmed-article:20956305 | pubmed:dateCreated | 2010-11-3 | lld:pubmed |
| pubmed-article:20956305 | pubmed:abstractText | The proper function of the bone morphogenic protein (BMP) pathway during embryonic development and organ maintenance requires its communication with other signaling pathways. Unlike the well-documented regulation of the BMP pathway by FGF/MAPK and Wnt/GSK3 signals, cross-talk between BMP/Smad and retinoic acid (RA)/RA receptor (RAR) pathways is poorly understood. Here, we show that RA represses BMP signal duration by reducing the level of phosphorylated Smad1 (pSmad1). Through its nuclear receptor-mediated transcription, RA enhances the interaction between pSmad1 and its ubiquitin E3 ligases, thereby promoting pSmad1 ubiquitination and proteasomal degradation. This regulation depends on the RA-increased Gadd45 expression and MAPK activation. During the neural development in chicken embryo, the RA/RAR pathway also suppresses BMP signaling to antagonize BMP-regulated proliferation and differentiation of neural progenitor cells. Furthermore, this cross-talk between RA and BMP pathways is involved in the proper patterning of dorsal neural tube of chicken embryo. Our results reveal a mechanism by which RA suppresses BMP signaling through regulation of pSmad1 stability. | lld:pubmed |
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| pubmed-article:20956305 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20956305 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20956305 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20956305 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20956305 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:WangChenC | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:ChenYe-GuangY... | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:LinAnningA | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:JingNaiheN | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:GuillemotFran... | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:XieZhihuiZ | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:SongJianguoJ | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:BaiGeG | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:ZhangKejingK | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:ShengNengyinN | lld:pubmed |
| pubmed-article:20956305 | pubmed:author | pubmed-author:ZhuQingqingQ | lld:pubmed |
| pubmed-article:20956305 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20956305 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:20956305 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20956305 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20956305 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20956305 | pubmed:pagination | 18886-91 | lld:pubmed |
| pubmed-article:20956305 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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