| pubmed-article:20863598 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C0006974 | lld:lifeskim |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C1519554 | lld:lifeskim |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20863598 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:20863598 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:20863598 | pubmed:dateCreated | 2010-10-11 | lld:pubmed |
| pubmed-article:20863598 | pubmed:abstractText | New 1,5-dihydro-4-(substituted phenyl)-3H-furo[3,4-b]carbazol-3-ones were synthesised via a key step Diels-Alder reaction under microwave irradiation. 3-Formylindole was successfully used in a 6-step synthesis to obtain those complex heterocycles. The Diels-Alder reaction generating the carbazole ring was optimised under thermal conditions or microwave irradiation. After cleavage of functional groups, DNA binding, topoisomerase inhibition and cytotoxic properties of the new-formed furocarbazoles were investigated. These carbazoles do not present a strong interaction with the DNA, and do not modify the relaxation of the DNA in the presence of topoisomerase I or II except for one promising compound. This compound is a potent topoisomerase II inhibitor, and its cellular activity is not moderated compared to etoposide. The synthesis of these molecules allowed the generalisation of the method using indole and 5-OBn indole and several benzaldehydes. The synthesis of these molecules produced chemical structures endowed with promising cytotoxic and topoisomerase II inhibition activities. | lld:pubmed |
| pubmed-article:20863598 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20863598 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863598 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20863598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863598 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20863598 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20863598 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20863598 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:BaldeyrouBrig... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:BaillyChristi... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:MérourJean-Yv... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:LansiauxAméli... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:RoutierSylvai... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:ChillouxAurél... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:VedrenneEmeli... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:HajbiYoussefY | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:NeagoieCléopa... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:BiannicBéreng... | lld:pubmed |
| pubmed-article:20863598 | pubmed:author | pubmed-author:RoscaSorinS | lld:pubmed |
| pubmed-article:20863598 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:20863598 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20863598 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:20863598 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20863598 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20863598 | pubmed:pagination | 5428-37 | lld:pubmed |
| pubmed-article:20863598 | pubmed:meshHeading | pubmed-meshheading:20863598... | lld:pubmed |
| pubmed-article:20863598 | pubmed:meshHeading | pubmed-meshheading:20863598... | lld:pubmed |
| pubmed-article:20863598 | pubmed:meshHeading | pubmed-meshheading:20863598... | lld:pubmed |
| pubmed-article:20863598 | pubmed:meshHeading | pubmed-meshheading:20863598... | lld:pubmed |
| pubmed-article:20863598 | pubmed:meshHeading | pubmed-meshheading:20863598... | lld:pubmed |
| pubmed-article:20863598 | pubmed:meshHeading | pubmed-meshheading:20863598... | lld:pubmed |
| pubmed-article:20863598 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20863598 | pubmed:articleTitle | Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors. | lld:pubmed |
| pubmed-article:20863598 | pubmed:affiliation | Institut de Chimie Organique et Analytique, Université d'Orléans, CNRS UMR 6005, B.P. 6759, 45067 Orléans Cedex 2, France. | lld:pubmed |
| pubmed-article:20863598 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20863598 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20863598 | lld:chembl |
