| pubmed-article:20861327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20861327 | lifeskim:mentions | umls-concept:C0038172 | lld:lifeskim |
| pubmed-article:20861327 | lifeskim:mentions | umls-concept:C0038411 | lld:lifeskim |
| pubmed-article:20861327 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:20861327 | lifeskim:mentions | umls-concept:C0015309 | lld:lifeskim |
| pubmed-article:20861327 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:20861327 | lifeskim:mentions | umls-concept:C0304231 | lld:lifeskim |
| pubmed-article:20861327 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:20861327 | pubmed:dateCreated | 2010-11-2 | lld:pubmed |
| pubmed-article:20861327 | pubmed:abstractText | Staphylococcus aureus and Streptococcus pyogenes secrete exotoxins that act as superantigens, proteins that cause hyperimmune reactions by binding the variable domain of the T-cell receptor beta chain (V?), leading to stimulation of a large fraction of the T-cell repertoire. To develop potential neutralizing agents, we engineered V? mutants with high affinity for the superantigens staphylococcal enterotoxin B (SEB), SEC3, and streptococcal pyrogenic exotoxin A (SpeA). Unexpectedly, the high-affinity V? mutants generated against SEB cross-reacted with SpeA to a greater extent than they did with SEC3, despite greater sequence similarity between SEB and SEC3. Likewise, the V? mutants generated against SpeA cross-reacted with SEB to a greater extent than with SEC3. The structural basis of the high affinity and cross-reactivity was examined by single-site mutational analyses. The cross-reactivity seems to involve only one or two toxin residues. Soluble forms of the cross-reactive V? regions neutralized both SEB and SpeA in vivo, suggesting structure-based strategies for generating high-affinity neutralizing agents that can cross-react with multiple exotoxins. | lld:pubmed |
| pubmed-article:20861327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20861327 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20861327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20861327 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20861327 | pubmed:issn | 1556-679X | lld:pubmed |
| pubmed-article:20861327 | pubmed:author | pubmed-author:SchlievertPat... | lld:pubmed |
| pubmed-article:20861327 | pubmed:author | pubmed-author:SundbergEric... | lld:pubmed |
| pubmed-article:20861327 | pubmed:author | pubmed-author:KranzDavid... | lld:pubmed |
| pubmed-article:20861327 | pubmed:author | pubmed-author:WangNingyanN | lld:pubmed |
| pubmed-article:20861327 | pubmed:author | pubmed-author:MattisDaiva... | lld:pubmed |
| pubmed-article:20861327 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20861327 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:20861327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20861327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20861327 | pubmed:pagination | 1781-9 | lld:pubmed |
| pubmed-article:20861327 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
| pubmed-article:20861327 | pubmed:meshHeading | pubmed-meshheading:20861327... | lld:pubmed |
