| pubmed-article:20837340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20837340 | lifeskim:mentions | umls-concept:C0665952 | lld:lifeskim |
| pubmed-article:20837340 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:20837340 | lifeskim:mentions | umls-concept:C0679426 | lld:lifeskim |
| pubmed-article:20837340 | lifeskim:mentions | umls-concept:C1135976 | lld:lifeskim |
| pubmed-article:20837340 | lifeskim:mentions | umls-concept:C0445356 | lld:lifeskim |
| pubmed-article:20837340 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20837340 | pubmed:dateCreated | 2010-9-14 | lld:pubmed |
| pubmed-article:20837340 | pubmed:abstractText | Donor killer cell immunoglobulin-like receptor (KIR) ligand incompatibility in the graft-versus-host direction is associated with decreased relapse incidence and improved disease-free survival after haploidentical and human leucocyte antigen (HLA)-mismatched unrelated, haematopoietic stem cell transplantation. However, review of all published studies of allogeneic HLA-matched or mismatched stem cell transplantation shows that the results on the relationship between donor-recipient KIR(-ligand) (in)compatibility and outcomes are highly variable, ranging from highly beneficial to detrimental. Reasons for these differences may include the methodology to determine KIR(-ligand) incompatibility, the disease distribution and the transplant protocol or donor type. Two retrospective studies on the effects of KIR-ligand incompatibility in unrelated cord blood transplantation (UCBT) for haematological malignancies have resulted in conflicting results. The Eurocord study showed a favourable effect of KIR-ligand mismatching on relapse incidence and leukaemia-free survival, whereas the Minneapolis study showed no effect on these end points and a detrimental effect on incidence of graft-versus-host disease (GvHD). In patients with non-malignant disorders, KIR-ligand (in)compatibility between donor and recipient was not associated with outcomes in a recent Eurocord analysis. Therefore, the role of natural killer (NK) cell alloreactivity in UCBT is far from clear. It is too early to use a donor-recipient KIR(-ligand) algorithm for selection of a cord blood donor. | lld:pubmed |
| pubmed-article:20837340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20837340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20837340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20837340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20837340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20837340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20837340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20837340 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20837340 | pubmed:issn | 1532-1924 | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:WillemzeRoelR | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:GluckmanElian... | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:RochaVanderso... | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:RodriguesCels... | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:RuggeriAnnali... | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:PurtillDuncan... | lld:pubmed |
| pubmed-article:20837340 | pubmed:author | pubmed-author:Eurocord... | lld:pubmed |
| pubmed-article:20837340 | pubmed:copyrightInfo | Copyright © 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20837340 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20837340 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:20837340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20837340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20837340 | pubmed:pagination | 283-90 | lld:pubmed |
| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
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| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
| pubmed-article:20837340 | pubmed:meshHeading | pubmed-meshheading:20837340... | lld:pubmed |
| pubmed-article:20837340 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20837340 | pubmed:articleTitle | Is there an impact of killer cell immunoglobulin-like receptors and KIR-ligand incompatibilities on outcomes after unrelated cord blood stem cell transplantation? | lld:pubmed |
| pubmed-article:20837340 | pubmed:affiliation | Department of Hematology, Leiden University Medical Center, the Netherlands. R.Willemze@lumc.nl | lld:pubmed |
| pubmed-article:20837340 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20837340 | pubmed:publicationType | Review | lld:pubmed |
