| pubmed-article:20825206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20825206 | lifeskim:mentions | umls-concept:C0995557 | lld:lifeskim |
| pubmed-article:20825206 | lifeskim:mentions | umls-concept:C0208355 | lld:lifeskim |
| pubmed-article:20825206 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20825206 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20825206 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:20825206 | pubmed:dateCreated | 2010-9-24 | lld:pubmed |
| pubmed-article:20825206 | pubmed:abstractText | Material collected from a parkway in the city of Chicago afforded the isolation of a Nostoc species (UIC 10022A). The extract of this strain displayed significant inhibition of the 20S proteasome as well as antiproliferative activity against HT29, MCF7, NCI-H460, and SF268 cancer cell lines. A standardized dereplication protocol allowed for the rapid identification of three known (11-13) and nine new (1-9) chlorinated cylindrocyclophanes from less than 100 mg of organic extract. Scale-up isolation of 1-9 and 11-13 from a larger extract was guided by LC-UV-MS data. In addition, KBr enrichment of the culture media afforded the isolation of a brominated cylindrocyclophane (10). Biological evaluation of 1-5, 9, and 10-13 revealed a large range of activity against the 20S proteasome and allowed the determination of preliminary structure-activity relationships of the cylindrocyclophane pharmacophore. | lld:pubmed |
| pubmed-article:20825206 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20825206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20825206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20825206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20825206 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20825206 | pubmed:issn | 1520-6025 | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:SwansonSteven... | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:LantvitDaniel... | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:ShenQiQ | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:KrunicAleksej... | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:OrjalaJimmyJ | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:PorterKyleK | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:SturdyMeganM | lld:pubmed |
| pubmed-article:20825206 | pubmed:author | pubmed-author:ChlipalaGeorg... | lld:pubmed |
| pubmed-article:20825206 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20825206 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:20825206 | pubmed:volume | 73 | lld:pubmed |
| pubmed-article:20825206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20825206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20825206 | pubmed:pagination | 1529-37 | lld:pubmed |
| pubmed-article:20825206 | pubmed:dateRevised | 2011-9-30 | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:meshHeading | pubmed-meshheading:20825206... | lld:pubmed |
| pubmed-article:20825206 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20825206 | pubmed:articleTitle | Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp. | lld:pubmed |
| pubmed-article:20825206 | pubmed:affiliation | Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60612, USA. | lld:pubmed |
| pubmed-article:20825206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20825206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20825206 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20825206 | lld:chembl |
