| pubmed-article:207880 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C1524059 | lld:lifeskim |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C0014930 | lld:lifeskim |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C0752229 | lld:lifeskim |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:207880 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:207880 | pubmed:issue | 2-3 | lld:pubmed |
| pubmed-article:207880 | pubmed:dateCreated | 1978-8-28 | lld:pubmed |
| pubmed-article:207880 | pubmed:abstractText | The uterotropic and antiuterotrapic effects of a variety of structural derivatives of the nonsteroidal antiestrogen tamoxifen have been determined in the rat and the mouse. One derivative, monohydroxytamoxifen, was found to be a potent antiestrogen in the rat, with a high affinity for the estrogen receptor. Various techniques of sucrose density gradient analysis were used to demonstrate that estradiol and tamoxifen bind to the rat uterine cytoplasmic estrogen receptor. Estrogens and antiestrogens provoke the translocation of estrogen receptors to the nucleus and deplete the cytoplasmic estrogen receptor pool for short or long periods depending on the dose administered. Estradiol stimulates endometrial hyperplasia with an increase in total uterine DNA content, whereas tamoxifen stimulates endometrial hypertrophy with only a slight increase in uterine DNA content. It is concluded that the molecular shape of the ligand that binds to the estrogen receptor determines antiestrogenic activity. | lld:pubmed |
| pubmed-article:207880 | pubmed:language | eng | lld:pubmed |
| pubmed-article:207880 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:207880 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:207880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:207880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:207880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:207880 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:207880 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:207880 | pubmed:issn | 0098-4108 | lld:pubmed |
| pubmed-article:207880 | pubmed:author | pubmed-author:JordanV CVC | lld:pubmed |
| pubmed-article:207880 | pubmed:author | pubmed-author:DixC JCJ | lld:pubmed |
| pubmed-article:207880 | pubmed:author | pubmed-author:RowsbyLL | lld:pubmed |
| pubmed-article:207880 | pubmed:author | pubmed-author:PrestwichGG | lld:pubmed |
| pubmed-article:207880 | pubmed:author | pubmed-author:NaylorK EKE | lld:pubmed |
| pubmed-article:207880 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:207880 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:207880 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:207880 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:207880 | pubmed:pagination | 363-90 | lld:pubmed |
| pubmed-article:207880 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:207880 | pubmed:meshHeading | pubmed-meshheading:207880-A... | lld:pubmed |
| pubmed-article:207880 | pubmed:meshHeading | pubmed-meshheading:207880-U... | lld:pubmed |
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| pubmed-article:207880 | pubmed:meshHeading | pubmed-meshheading:207880-R... | lld:pubmed |
| pubmed-article:207880 | pubmed:articleTitle | Nonsteroidal antiestrogens: their biological effects and potential mechanisms of action. | lld:pubmed |
| pubmed-article:207880 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:207880 | pubmed:publicationType | In Vitro | lld:pubmed |
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