| pubmed-article:20725138 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C1948041 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C1414262 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C1414263 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C2348358 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20725138 | lifeskim:mentions | umls-concept:C1720127 | lld:lifeskim |
| pubmed-article:20725138 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20725138 | pubmed:dateCreated | 2010-8-20 | lld:pubmed |
| pubmed-article:20725138 | pubmed:abstractText | Endothelin (ET) receptor antagonists are antihypertensive and renoprotective in angiotensin II (AngII)-induced hypertension if administered when AngII infusion commences, but their effects on established hypertension are poorly understood. We therefore tested the effects of intervening with an ETA (ABT-627) or ETB (A-192621) receptor antagonist after establishing hypertension with AngII (65 ng/min s.c.) plus 8% NaCl diet (AngII-HS) in rats. Prior to administration of ABT-627, AngII-HS and AngII-HS plus ABT-627 groups displayed robust hypertension (mean arterial pressure (MAP), 170 +/- 5 and 165 +/- 5 mm Hg versus 110 +/- 3 mm Hg in normal salt control rats at day 7, P < 0.05). Administering ABT-627 from day 8 of AngII-HS treatment prevented further rises in MAP (168 +/- 5 and 191 +/- 3 mm Hg at day 13 in AngII-HS plus ABT-627 and AngII-HS, P < 0.001), without blunting the significant increases in urinary protein (19-fold), albumin (25-fold), or MCP-1 excretion (6- to 8-fold) or the reduction in creatinine clearance. Administering A-192621 from day 8 mildly exacerbated AngII-HS induced hypertension (P < 0.05 for AngII-HS versus AngII-HS plus A-192621 on days 11 and 12 only) and reduced plasma nitrite/nitrate concentration (P < 0.05), without affecting proteinuria, albuminuria, or creatinine clearance. These results confirm the importance of ETA receptor signaling in maintaining AngII-HS hypertension and suggest that including ETB receptor blockade in therapeutic approaches to treating hypertension would be ineffective or even counterproductive. | lld:pubmed |
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| pubmed-article:20725138 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20725138 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20725138 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20725138 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20725138 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20725138 | pubmed:issn | 1205-7541 | lld:pubmed |
| pubmed-article:20725138 | pubmed:author | pubmed-author:PollockDavid... | lld:pubmed |
| pubmed-article:20725138 | pubmed:author | pubmed-author:PollockJennif... | lld:pubmed |
| pubmed-article:20725138 | pubmed:author | pubmed-author:BoesenErika... | lld:pubmed |
| pubmed-article:20725138 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20725138 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:20725138 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20725138 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20725138 | pubmed:pagination | 802-7 | lld:pubmed |
| pubmed-article:20725138 | pubmed:dateRevised | 2011-7-26 | lld:pubmed |
| pubmed-article:20725138 | pubmed:meshHeading | pubmed-meshheading:20725138... | lld:pubmed |
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| pubmed-article:20725138 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20725138 | pubmed:articleTitle | Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. | lld:pubmed |
| pubmed-article:20725138 | pubmed:affiliation | Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Boulevard, Augusta, GA 30912, USA. eboesen@mcg.edu | lld:pubmed |
| pubmed-article:20725138 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20725138 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20725138 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
