| pubmed-article:20706984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20706984 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:20706984 | lifeskim:mentions | umls-concept:C2936411 | lld:lifeskim |
| pubmed-article:20706984 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:20706984 | lifeskim:mentions | umls-concept:C0679932 | lld:lifeskim |
| pubmed-article:20706984 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:20706984 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:20706984 | pubmed:dateCreated | 2010-9-2 | lld:pubmed |
| pubmed-article:20706984 | pubmed:abstractText | Th17 cells and Th1 cells coordinate to play a critical role in the formation of inflammatory bowel diseases. To examine how Th17 and Th1 cells are regulated at inflammatory sites, we used Th1-dominant CD4(+)CD45RB(high) T cell-transferred RAG-2(-/-) and Th1/Th17-mixed IL-10(-/-) mice. Interestingly, not only did colitic RAG-2(-/-) mice that were parabiosed with WT mice show significant amelioration of colitis, but amelioration of disease was also observed in those parabiosed with colitic IL-10(-/-) mice. To assess the interference between Th1 and Th17 colitogenic T cells, we co-transferred colitogenic CD4(+) T cells from the lamina propria (LP) of CD4(+)CD45RB(high) T cell-transferred RAG-2(-/-) mice and IL-10(-/-) mice into RAG-2(-/-) mice. Surprisingly, the co-transferred RAG-2(-/-) mice showed a vast cellular infiltration of LP CD4(+) T cells similar to that seen in RAG-2(-/-) mice re-transferred with the cells from colitic RAG-2(-/-) mice alone, but the co-transferred RAG-2(-/-) mice did not have the wasting symptoms, which are also absent in RAG-2(-/-) mice transferred with cells from colitic IL-10(-/-) mice alone. Furthermore, the percentages of Th1 and Th17 cells originating from IL-10(-/-) mice and those of Th1 cells originating from colitic RAG-2(-/-) mice were all significantly decreased in the co-transferred mice as compared with the singly-transferred paired RAG-2(-/-) mice, suggesting that Th1 and Th17 cells are in competition, and that their orchestration results in a merged clinical phenotype of the two types of murine colitis. | lld:pubmed |
| pubmed-article:20706984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20706984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20706984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20706984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20706984 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20706984 | pubmed:issn | 1521-4141 | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:OnoYuichiY | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:OkamotoSusumu... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:HibiToshifumi... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:HayashiAtsush... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:InoueNagamuN | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:OgataHaruhiko... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:KanaiTakanori... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:TakaishiHirom... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:OkazawaAkiraA | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:HisamatsuTada... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:KamadaNobuhik... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:MatsuokaKatsu... | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:MikamiYoheiY | lld:pubmed |
| pubmed-article:20706984 | pubmed:author | pubmed-author:SujinoTomohis... | lld:pubmed |
| pubmed-article:20706984 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20706984 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:20706984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20706984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20706984 | pubmed:pagination | 2409-22 | lld:pubmed |
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| pubmed-article:20706984 | pubmed:meshHeading | pubmed-meshheading:20706984... | lld:pubmed |
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| pubmed-article:20706984 | pubmed:meshHeading | pubmed-meshheading:20706984... | lld:pubmed |
| pubmed-article:20706984 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20706984 | pubmed:articleTitle | Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis. | lld:pubmed |
| pubmed-article:20706984 | pubmed:affiliation | Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:20706984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20706984 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
