| pubmed-article:20691733 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C0520499 | lld:lifeskim |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20691733 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20691733 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20691733 | pubmed:dateCreated | 2010-9-29 | lld:pubmed |
| pubmed-article:20691733 | pubmed:abstractText | A primary therapeutic goal in Alzheimer's disease (AD) is to reduce the quantity of amyloid ? protein (A?) present in the brain. To develop an effective, safe system for vaccination against Alzheimer's disease, the plant virus Cucumber mosaic virus (CMV) was engineered genetically to express A?-derived fragments that stimulate mainly humoral immune responses. Six chimeric constructs, bearing the A?1-15 or the A?4-15 sequence in positions 248, 392 or 529 of the CMV coat protein (CP) gene, were created. Viral products proved to be able to replicate in their natural host. However, only chimeric A?1-15-CMVs were detected by A?1-42 antiserum in Western blot analysis. Experimental evidence of Immunoelectron microscopy revealed a complete decoration of A?1-15-CMV(248) and A?1-15-CMV(392) following incubation with either anti-A?1-15 or anti-A?1-42 polyclonal antibodies. These two chimeric CMVs appear to be endowed with features making them possible candidates for vaccination against Alzheimer's disease. | lld:pubmed |
| pubmed-article:20691733 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20691733 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691733 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20691733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691733 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20691733 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20691733 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20691733 | pubmed:issn | 1879-0984 | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:AntonaciSS | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:PiazzollaPP | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:BosciaDD | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:TortorellaCC | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:VitteEE | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:PiazzollaGG | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:De StradisAA | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:NuzzaciMM | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:LanorteM TMT | lld:pubmed |
| pubmed-article:20691733 | pubmed:author | pubmed-author:CondelliVV | lld:pubmed |
| pubmed-article:20691733 | pubmed:copyrightInfo | Copyright © 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:20691733 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20691733 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:20691733 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20691733 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20691733 | pubmed:pagination | 332-40 | lld:pubmed |
| pubmed-article:20691733 | pubmed:meshHeading | pubmed-meshheading:20691733... | lld:pubmed |
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| pubmed-article:20691733 | pubmed:meshHeading | pubmed-meshheading:20691733... | lld:pubmed |
| pubmed-article:20691733 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20691733 | pubmed:articleTitle | Cucumber mosaic virus as the expression system for a potential vaccine against Alzheimer's disease. | lld:pubmed |
| pubmed-article:20691733 | pubmed:affiliation | Department of Biology, Plant Protection and Agrobiotechnology, University of Basilicata, Viale dell'Ateneo Lucano, 10, 85100 Potenza, Italy. | lld:pubmed |
| pubmed-article:20691733 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20691733 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
