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pubmed-article:20691641pubmed:abstractTextSpinal and bulbar muscular atrophy is a hereditary motor neuron disease caused by the expansion of a polyglutamine tract in the androgen receptor. At present there are no treatments for spinal and bulbar muscular atrophy, although leuprorelin suppressed the accumulation of pathogenic androgen receptors in a phase 2 trial. We aimed to assess the efficacy and safety of leuprorelin for spinal and bulbar muscular atrophy.lld:pubmed
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pubmed-article:20691641pubmed:copyrightInfoCopyright 2010 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:20691641pubmed:articleTitleEfficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial.lld:pubmed
pubmed-article:20691641pubmed:affiliationDepartment of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.lld:pubmed
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pubmed-article:20691641pubmed:publicationTypeRandomized Controlled Triallld:pubmed
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