| pubmed-article:20661454 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C0033074 | lld:lifeskim |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C1579762 | lld:lifeskim |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C1883559 | lld:lifeskim |
| pubmed-article:20661454 | lifeskim:mentions | umls-concept:C0009491 | lld:lifeskim |
| pubmed-article:20661454 | pubmed:dateCreated | 2010-7-27 | lld:pubmed |
| pubmed-article:20661454 | pubmed:abstractText | Insulin-like growth factor-I (IGF-I) belongs to the family of insulin-related peptides that fulfils a key role during the late development of the nervous system. Human IGF1 mutations cause profound deafness, poor growth and mental retardation. Accordingly, Igf1(-/-) null mice are dwarfs that have low survival rates, cochlear alterations and severe sensorineural deafness. Presbycusis (age-related hearing loss) is a common disorder associated with aging that causes social and cognitive problems. Aging is also associated with a decrease in circulating IGF-I levels and this reduction has been related to cognitive and brain alterations, although there is no information as yet regarding the relationship between presbycusis and IGF-I biodisponibility. Here we present a longitudinal study of wild type Igf1(+/+) and null Igf1(-/-) mice from 2 to 12 months of age comparing the temporal progression of several parameters: hearing, brain morphology, cochlear cytoarchitecture, insulin-related factors and IGF gene expression and IGF-I serum levels. Complementary invasive and non-invasive techniques were used, including auditory brainstem-evoked response (ABR) recordings and in vivo MRI brain imaging. Igf1(-/-) null mice presented profound deafness at all the ages studied, without any obvious worsening of hearing parameters with aging. Igf1(+/+) wild type mice suffered significant age-related hearing loss, their auditory thresholds and peak I latencies augmenting as they aged, in parallel with a decrease in the circulating levels of IGF-I. Accordingly, there was an age-related spiral ganglion degeneration in wild type mice that was not evident in the Igf1 null mice. However, the Igf1(-/-) null mice in turn developed a prematurely aged stria vascularis reminiscent of the diabetic strial phenotype. Our data indicate that IGF-I is required for the correct development and maintenance of hearing, supporting the idea that IGF-I-based therapies could contribute to prevent or ameliorate age-related hearing loss. | lld:pubmed |
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| pubmed-article:20661454 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20661454 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20661454 | pubmed:status | PubMed-not-MEDLINE | lld:pubmed |
| pubmed-article:20661454 | pubmed:issn | 1662-5129 | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:Varela-NietoI... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:RiquelmeRaque... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:ContrerasJuli... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:Hernandez-San... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:CedielRafaelR | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:ZubeldiaJose... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:CerdanSebasti... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:Murillo-Cuest... | lld:pubmed |
| pubmed-article:20661454 | pubmed:author | pubmed-author:la Rosa... | lld:pubmed |
| pubmed-article:20661454 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20661454 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:20661454 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20661454 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20661454 | pubmed:pagination | 27 | lld:pubmed |
| pubmed-article:20661454 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20661454 | pubmed:articleTitle | A comparative study of age-related hearing loss in wild type and insulin-like growth factor I deficient mice. | lld:pubmed |
