Linked Life Data

20660818

Source:http://linkedlifedata.com/resource/pubmed/id/20660818

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pubmed-article:20660818pubmed:abstractTextPrevious studies in ovine uterine arteries have demonstrated that sex steroid hormones upregulate extracellular signal-regulated kinase 1/2 expression and downregulate the protein kinase C signaling pathway, resulting in the attenuated myogenic tone in pregnancy. The present study tested the hypothesis that chronic hypoxia during gestation inhibits the sex steroid-mediated adaptation of extracellular signal-regulated kinase 1/2 and protein kinase C signaling pathways and increases the myogenic tone of uterine arteries. Uterine arteries were isolated from nonpregnant and near-term pregnant sheep that had been maintained at sea level (?300 m) or exposed to high-altitude (3801 m) hypoxia for 110 days. In contrast to the previous findings in normoxic animals, 17?-estradiol and progesterone failed to suppress protein kinase C-induced contractions and the pressure-induced myogenic tone in uterine arteries from hypoxic animals. Western analyses showed that the sex steroids lost their effects on extracellular signal-regulated kinase 1/2 expression and phospho- extracellular signal-regulated kinase 1/2 levels, as well as the activation of protein kinase C isozymes in uterine arteries of hypoxic ewes. In normoxic animals, pregnancy and the sex steroid treatments significantly increased uterine artery estrogen receptor-? and progesterone receptor B expression. Chronic hypoxia selectively downregulated estrogen receptor-? expression in uterine arteries of pregnant animals and eliminated the upregulation of estrogen receptor-? in pregnancy or by the steroid treatments observed in normoxic animals. The results demonstrate that, in the ovine uterine artery, chronic hypoxia in pregnancy inhibits the sex steroid hormone-mediated adaptation of decreased myogenic tone by downregulating estrogen receptor-? expression, providing a mechanism linking hypoxia and maladaptation of uteroplacental circulation and an increased risk of preeclampsia in pregnancy.lld:pubmed
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pubmed-article:20660818pubmed:authorpubmed-author:ZhangLuboLlld:pubmed
pubmed-article:20660818pubmed:authorpubmed-author:LongoLawrence...lld:pubmed
pubmed-article:20660818pubmed:authorpubmed-author:HuangXiaohuiXlld:pubmed
pubmed-article:20660818pubmed:authorpubmed-author:YangShumeiSlld:pubmed
pubmed-article:20660818pubmed:authorpubmed-author:XiaoDaLiaoDlld:pubmed
pubmed-article:20660818pubmed:authorpubmed-author:ChangKatherin...lld:pubmed
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pubmed-article:20660818pubmed:dateRevised2011-10-3lld:pubmed
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pubmed-article:20660818pubmed:articleTitleChronic hypoxia inhibits sex steroid hormone-mediated attenuation of ovine uterine arterial myogenic tone in pregnancy.lld:pubmed
pubmed-article:20660818pubmed:affiliationCenter for Perinatal Biology, Department of Physiology and Pharmacology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA.lld:pubmed
pubmed-article:20660818pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20660818pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed