| pubmed-article:20652022 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0041296 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0079161 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0332185 | lld:lifeskim |
| pubmed-article:20652022 | lifeskim:mentions | umls-concept:C0205157 | lld:lifeskim |
| pubmed-article:20652022 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20652022 | pubmed:dateCreated | 2010-7-23 | lld:pubmed |
| pubmed-article:20652022 | pubmed:abstractText | Interferon (IFN)-gamma release assays (IGRA) have improved tuberculosis contact tracing, but discrimination of recent from remote Mycobacterium tuberculosis contacts is not possible by IGRA alone. We present results of a tuberculosis contact investigation with a new early-secretory-antigenic-target (ESAT)-6 and culture-filtrate-protein (CFP)-10 specific interleukin (IL)-2 ELISpot in addition to ESAT-6 and CFP-10 specific IFN-gamma ELISpot and tuberculin skin testing (TST). Results of the TST, IFN-gamma ELISpot and IL-2 ELISpot were positive in 6/172 (3.4%), 7/167 (4.2%) and 6/196 (3.1%) of contacts, respectively. Close contact (> or =100 hours) to the index case increased the risk of positive results in the IFN-gamma ELISpot, TST, and IL-2 ELISpot by 40.8, 19.3, and 2.5 times, respectively. Individuals with a positive IFN-gamma ELISpot/negative IL-2 ELISpot result had a median (IQR) duration of index case exposure of 568 hours (133_1000) compared to individuals with a positive IFN-gamma ELISpot/positive IL-2 ELISpot result (median = 24 hours; 20_130; p-value = 0.047). Combination of a M. tuberculosis specific IFN-gamma ELISpot with a M. tuberculosis specific IL-2 ELISpot significantly improved the identification of individuals with the highest risk of recent M. tuberculosis infection and is a promising method that should be explored to target tuberculosis preventive chemotherapy. | lld:pubmed |
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| pubmed-article:20652022 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20652022 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20652022 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20652022 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20652022 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:ReilingNorber... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:MartinErnstE | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:SotgiuGiovann... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:LangeChristop... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:StrassburgAla... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:HoersterRober... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:EkerBarbaraB | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:KrummelBenjam... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:RathHeidrunH | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:WapplerWaltra... | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:GlaeweAndreaA | lld:pubmed |
| pubmed-article:20652022 | pubmed:author | pubmed-author:SchoellhornVo... | lld:pubmed |
| pubmed-article:20652022 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20652022 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:20652022 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20652022 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20652022 | pubmed:pagination | e11670 | lld:pubmed |
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| pubmed-article:20652022 | pubmed:meshHeading | pubmed-meshheading:20652022... | lld:pubmed |
| pubmed-article:20652022 | pubmed:meshHeading | pubmed-meshheading:20652022... | lld:pubmed |
| pubmed-article:20652022 | pubmed:meshHeading | pubmed-meshheading:20652022... | lld:pubmed |
| pubmed-article:20652022 | pubmed:meshHeading | pubmed-meshheading:20652022... | lld:pubmed |
| pubmed-article:20652022 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20652022 | pubmed:articleTitle | Potential role for IL-2 ELISpot in differentiating recent and remote infection in tuberculosis contact tracing. | lld:pubmed |
| pubmed-article:20652022 | pubmed:affiliation | Division of Clinical Infectious Diseases, Research Center Borstel, Borstel, Germany. | lld:pubmed |
| pubmed-article:20652022 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20652022 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
