| pubmed-article:20639459 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C0172537 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20639459 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:20639459 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20639459 | pubmed:dateCreated | 2011-5-2 | lld:pubmed |
| pubmed-article:20639459 | pubmed:abstractText | We reported that inhibiting matrix metalloproteinases (MMP), known to remodel the extracellular matrix, also down-regulated antigen-specific T-cell responses. However, the direct role of MMP2 and MMP9 in regulating intracellular function in T cells is unknown. Markers of cellular activation and cytokine profiles were examined in anti-CD3-stimulated wild-type C57BL/6 mouse-derived CD4(+) or CD8(+) T cells, or MMP2- or MMP9-deficient (-/-) mice. MMP-sufficient T cells were also treated with SB-3CT, a highly selective inhibitor of MMP2 and MMP9. The effect of MMP-specific inhibition on T cell-dependent, antigen-specific murine lung injury was examined in vivo. SB-3CT induced dose-dependent reductions in anti-CD3-stimulated T-cell proliferation. Although MMP2(-/-) cells were reduced 20%, anti-CD3-induced proliferation was down-regulated 80-85% in MMP9(-/-) or in SB-3CT-treated wild-type CD4(+) and CD8(+) T cells. Intracellular calcium flux was augmented in response to MMP inhibition or deficiency in the same cells, and IL-2 production was reduced in CD4(+) and CD8(+) MMP9(-/-) T cells. SB-3CT-mediated MMP2 and MMP9 inhibition abrogated antigen-specific CD8(+) T cell-mediated lung injury in vivo. MMPs, particularly MMP9, may function intracellularly to regulate T-cell activation. T cell-targeted MMP inhibition may provide a novel approach of immune regulation in the treatment of T cell-mediated diseases. | lld:pubmed |
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| pubmed-article:20639459 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20639459 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20639459 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20639459 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20639459 | pubmed:month | May | lld:pubmed |
| pubmed-article:20639459 | pubmed:issn | 1535-4989 | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:KheradmandFar... | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:MobasheryShah... | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:WilkesDavid... | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:SmithGerald... | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:HongJeong... | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:ChangMaylandM | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:ShillingRebec... | lld:pubmed |
| pubmed-article:20639459 | pubmed:author | pubmed-author:BensonHeather... | lld:pubmed |
| pubmed-article:20639459 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20639459 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:20639459 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20639459 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20639459 | pubmed:pagination | 700-8 | lld:pubmed |
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| pubmed-article:20639459 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20639459 | pubmed:articleTitle | Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells. | lld:pubmed |
| pubmed-article:20639459 | pubmed:affiliation | Department of Biochemistry, Indiana University School of Medicine, Indianapolis, 46202, USA. | lld:pubmed |
| pubmed-article:20639459 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20639459 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20639459 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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