| pubmed-article:20636003 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20636003 | lifeskim:mentions | umls-concept:C0472699 | lld:lifeskim |
| pubmed-article:20636003 | lifeskim:mentions | umls-concept:C0079613 | lld:lifeskim |
| pubmed-article:20636003 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:20636003 | lifeskim:mentions | umls-concept:C0725066 | lld:lifeskim |
| pubmed-article:20636003 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20636003 | pubmed:dateCreated | 2010-7-19 | lld:pubmed |
| pubmed-article:20636003 | pubmed:abstractText | Although partially HLA-mismatched hematopoietic stem cell transplantation (HSCT) has become an important therapeutic option for children with primary immunodeficiencies, delayed reconstitution of the T-cell compartment remains a major clinical concern. Adoptive immunotherapies to provide recipients with a protective and diverse T-cell repertoire in the months following HSCT are warranted. In order to improve T-cell reconstitution after T-cell-depleted HSCT, different strategies are currently being studied. Some are based on administration of modified mature T cells (e.g., allodepleted T cells or pathogen-specific T cells). Others aim at accelerating de novo thymopoiesis from donor-derived hematopoietic stem cells in vivo via the administration of thymopoietic agents or the transfer of large numbers of T-cell precursors generated ex vivo. The present article will provide a brief summary of recent advances in the field of allodepletion and adoptive transfer of pathogen-specific T cells and a detailed discussion of strategies for enhancing thymopoiesis in vivo. | lld:pubmed |
| pubmed-article:20636003 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20636003 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20636003 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20636003 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20636003 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20636003 | pubmed:issn | 1750-7448 | lld:pubmed |
| pubmed-article:20636003 | pubmed:author | pubmed-author:FischerAlainA | lld:pubmed |
| pubmed-article:20636003 | pubmed:author | pubmed-author:Cavazzana-Cal... | lld:pubmed |
| pubmed-article:20636003 | pubmed:author | pubmed-author:André-Schmutz... | lld:pubmed |
| pubmed-article:20636003 | pubmed:author | pubmed-author:Hacein-Bey-Ab... | lld:pubmed |
| pubmed-article:20636003 | pubmed:author | pubmed-author:Dal... | lld:pubmed |
| pubmed-article:20636003 | pubmed:author | pubmed-author:ReimannChrist... | lld:pubmed |
| pubmed-article:20636003 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20636003 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:20636003 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20636003 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20636003 | pubmed:pagination | 481-96 | lld:pubmed |
| pubmed-article:20636003 | pubmed:meshHeading | pubmed-meshheading:20636003... | lld:pubmed |
| pubmed-article:20636003 | pubmed:meshHeading | pubmed-meshheading:20636003... | lld:pubmed |
| pubmed-article:20636003 | pubmed:meshHeading | pubmed-meshheading:20636003... | lld:pubmed |
| pubmed-article:20636003 | pubmed:meshHeading | pubmed-meshheading:20636003... | lld:pubmed |
| pubmed-article:20636003 | pubmed:meshHeading | pubmed-meshheading:20636003... | lld:pubmed |
| pubmed-article:20636003 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20636003 | pubmed:articleTitle | Advances in adoptive immunotherapy to accelerate T-cellular immune reconstitution after HLA-incompatible hematopoietic stem cell transplantation. | lld:pubmed |
| pubmed-article:20636003 | pubmed:affiliation | Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Biothérapie, Hopital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, and Université Paris Descartes 75015 Paris, France. | lld:pubmed |
| pubmed-article:20636003 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20636003 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:20636003 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
